{"id":100084,"date":"2018-03-11T10:21:28","date_gmt":"2018-03-11T10:21:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructurales-biofisicosbioquimicos-y-celulares-de-los-cofactores-de-tubulina-tbcb-y-tbcc\/"},"modified":"2018-03-11T10:21:28","modified_gmt":"2018-03-11T10:21:28","slug":"estudios-estructurales-biofisicosbioquimicos-y-celulares-de-los-cofactores-de-tubulina-tbcb-y-tbcc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/proteinas\/estudios-estructurales-biofisicosbioquimicos-y-celulares-de-los-cofactores-de-tubulina-tbcb-y-tbcc\/","title":{"rendered":"Estudios estructurales, biofisicos,bioquimicos y celulares de los cofactores de tubulina tbcb y tbcc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Casta\u00f1o Cobo <\/strong><\/h2>\n<p>Los microt\u00fabulos son pol\u00edmeros compuestos por subunidades de alfa- y beta-tubulina compuestos por 13 protofilametos. La formaci\u00f3n del heterod\u00edmero de alfa- y beta-tubulina es un proceso complicado y precisa una serie de cofactores proteicos que act\u00faan de manera coordenada para facilitar la asociaci\u00f3n de alfa con beta-tubulina e incorporarse al microt\u00fabulo tras la hidr\u00f3lisis de gtp  hasta la fecha se han identificado seis prote\u00ednas que intervienen en el proceso de formaci\u00f3n del heterod\u00edmero de tubulina in vitro, tras su liberaci\u00f3n de cct. Cinco de estas prote\u00ednas (a, b, c, d y e) participan directamente en la formaci\u00f3n del heterod\u00edmero. La sexta prote\u00edna, arl2, regula la actividad del cofactor d. En esta tesis se pretende dilucidar el posible papel etiopatog\u00e9nico que los genes de los cofactores de la tubulina (tbcs), vinculados a la din\u00e1mica microtubular, podr\u00edan ejercer en diferentes patolog\u00edas. concretamente, se han estudiado los cofactores tbcb y tbcc. Tbcb es una prote\u00edna de uni\u00f3n a \u00c2\u00bf-tubulina que participan en la biog\u00e9nesis de la tubulina y tbcc es la prote\u00edna con actividad gap encargada de liberar los heterod\u00edmeros de alfa,beta-tubulina competentes para incorporarse al microt\u00fabulo. Hemos estudiado las prote\u00ednas con el objeto de conocer y entender mejor su funci\u00f3n en la c\u00e9lula y los posibles efectos que se pueden producir cuando est\u00e9n alteradas. Para ello se han purificado ambas prote\u00ednas, se ha intentado resolver su estructura mediante difracci\u00f3n de rayos x o por rmn (consigui\u00e9ndose en el caso del dominio amino terminal de tbcc), se han realizado ensayos bioqu\u00edmicos, estudios de biolog\u00eda celular y de igual manera se han utilizado diferentes t\u00e9cnicas biof\u00edsicas que nos han ayudado a conocer m\u00e1s de cerca la naturaleza de ambas prote\u00ednas y a comprender mejor su funci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios estructurales, biofisicos,bioquimicos y celulares de los cofactores de tubulina tbcb y tbcc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios estructurales, biofisicos,bioquimicos y celulares de los cofactores de tubulina tbcb y tbcc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Casta\u00f1o Cobo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Zabala Ota\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Ortiz melon <\/li>\n<li>helena Soares (vocal)<\/li>\n<li>guillermo Montoya blanco (vocal)<\/li>\n<li>sofia Nolasco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Casta\u00f1o Cobo Los microt\u00fabulos son pol\u00edmeros compuestos por subunidades de alfa- y beta-tubulina compuestos por 13 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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