{"id":100087,"date":"2018-03-11T10:21:28","date_gmt":"2018-03-11T10:21:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sensibilizacion-del-melanoma-maligno-a-la-oncoterapia-deplecion-del-glutation-y-bcl-2\/"},"modified":"2018-03-11T10:21:28","modified_gmt":"2018-03-11T10:21:28","slug":"sensibilizacion-del-melanoma-maligno-a-la-oncoterapia-deplecion-del-glutation-y-bcl-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/metabolismo-intermediario\/sensibilizacion-del-melanoma-maligno-a-la-oncoterapia-deplecion-del-glutation-y-bcl-2\/","title":{"rendered":"Sensibilizaci\u00f3n del melanoma maligno a la oncoterapia. depleci\u00f3n del glutati\u00f3n y bcl-2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Salvador Mena Moll\u00e1 <\/strong><\/h2>\n<p>El melanoma maligno es uno de los c\u00e1nceres m\u00e1s letales. La sobreexpresi\u00f3n del proto-oncogen bcl-2 se asocia frecuentemente a una disminuci\u00f3n en la supervivencia de los pacientes. Niveles elevados de glutati\u00f3n (gsh, gamma-glu-cys-gly; el tiol no proteico prevalente en c\u00e9lulas eucariotas) y la prote\u00edna antiapopt\u00f3tica bcl-2 confieren quimio- y radiorresistencia. In vivo, la depleci\u00f3n selectiva de bcl-2 y gsh en c\u00e9lulas de melanoma murino b16-f10 (met\u00e1stasis hep\u00e1ticas) y humano a375 (xenoinjertos) se consigui\u00f3 utilizando: a) oligonucle\u00f3tidos antisentido anti-bcl-2 (oblimersen\u00f3 g3139; genta), y b) aceleraci\u00f3n del eflujo de gsh al espacio extracelular v\u00eda el uso combinado de una dieta rica en l-gln (que disminuye los niveles de gsh mitocondrial), verapamilo [activador de mrp1 (multi-drug resistance protein 1)], g3139 [potencia la salida de gsh a trav\u00e9s de un canal dependiente de bcl-2], y acv (inhibidor de la actividad de gamma-glutamil-transpeptidasa), induce una depleci\u00f3n selectiva de gsh en c\u00e9lulas tumorales in vivo.  la depleci\u00f3n selectiva de gsh y bcl-2 combina la especificidad y la eficacia: especificidad para eliminar s\u00f3lo las c\u00e9lulas tumorales sin afectar a las c\u00e9lulas sanas; y eficacia para sensibilizar a la acci\u00f3n citot\u00f3xica inducida por la oncoterapia convencional en condiciones cl\u00ednicamente aceptables. la terapia experimental planteada sensibiliza al modelo de met\u00e1stasis de melanoma murino b16-f10 y el modelo de melanoma humano a375 a la oncoterapia convencionales, siendo capaz de eliminar met\u00e1stasis hep\u00e1ticas de melanoma murino b16-f10 y tumores del melanoma humano a375 en crecimiento como xenoinjertos, sin afectar los par\u00e1metros fisiol\u00f3gicos y aumentando la supervivencia de los ratones tratados, indicando que la depleci\u00f3n de bcl-2 y gsh es una estrategia eficaz para la sensibilizaci\u00f3n a la oncoterapia frente el melanoma humano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sensibilizaci\u00f3n del melanoma maligno a la oncoterapia. depleci\u00f3n del glutati\u00f3n y bcl-2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sensibilizaci\u00f3n del melanoma maligno a la oncoterapia. depleci\u00f3n del glutati\u00f3n y bcl-2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Salvador Mena Moll\u00e1 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julian Carretero Asuncion<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Franco vera <\/li>\n<li>esteban Ballestar tarin (vocal)<\/li>\n<li>Juan Llopis borr\u00e1s (vocal)<\/li>\n<li>Jos\u00e9 Luis Garcia gimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Salvador Mena Moll\u00e1 El melanoma maligno es uno de los c\u00e1nceres m\u00e1s letales. La sobreexpresi\u00f3n del proto-oncogen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[257,1027,347],"tags":[75741,126878,176561,53834,11638,203998],"class_list":["post-100087","post","type-post","status-publish","format-standard","hentry","category-metabolismo-intermediario","category-oncologia","category-oncologia-clinica","tag-esteban-ballestar-tarin","tag-jose-luis-garcia-gimenez","tag-juan-llopis-borras","tag-julian-carretero-asuncion","tag-luis-franco-vera","tag-salvador-mena-molla"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=100087"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100087\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=100087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=100087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=100087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}