{"id":100225,"date":"2010-12-04T00:00:00","date_gmt":"2010-12-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-la-inhibicion-de-la-pge2-sobre-la-inflamacion-y-la-sintesis-de-mediadores-del-metabolismo-oseo-en-el-cartilago-articular-de-pacientes-con-artrosis\/"},"modified":"2010-12-04T00:00:00","modified_gmt":"2010-12-04T00:00:00","slug":"estudio-del-efecto-de-la-inhibicion-de-la-pge2-sobre-la-inflamacion-y-la-sintesis-de-mediadores-del-metabolismo-oseo-en-el-cartilago-articular-de-pacientes-con-artrosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-la-inhibicion-de-la-pge2-sobre-la-inflamacion-y-la-sintesis-de-mediadores-del-metabolismo-oseo-en-el-cartilago-articular-de-pacientes-con-artrosis\/","title":{"rendered":"Estudio del efecto de la inhibicion de la pge2 sobre la inflamacion y la sintesis de mediadores del metabolismo oseo en el cartilago articular de pacientes con artrosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Moreno Rubio <\/strong><\/h2>\n<p>La artrosis (oa) es la patolog\u00eda articular m\u00e1s frecuente. La caracter\u00edstica principal de la oa es la degeneraci\u00f3n del cart\u00edlago articular, aunque simult\u00e1neamente se producen cambios en el metabolismo de la membrana sinovial y del hueso subcondral, lo que provoca la aparici\u00f3n de dolor y rigidez y la disminuci\u00f3n de la funcionalidad. La pge2 es un mediador clave en la patogenia de la oa. El tratamiento m\u00e1s extendido para controlar los s\u00edntomas de la oa son los antiinflamatorios no esteroideos (aines). La eficacia terap\u00e9utica de los aines se atribuye a su capacidad de disminuir la liberaci\u00f3n de la pge2 mediante la inhibici\u00f3n de la actividad enzim\u00e1tica de la cox. Aunque actualmente estos f\u00e1rmacos se emplean durante largos periodos de tiempo, no se conocen con exactitud los efectos directos que tienen sobre el cart\u00edlago.  en esta tesis hemos demostrado que, una terapia prolongada con agentes bloqueantes de la pge2 disminuye la producci\u00f3n de pge2 no solo mediante la inhibici\u00f3n directa de las cox, sino tambi\u00e9n por la disminuci\u00f3n en la expresi\u00f3n y en la s\u00edntesis de la cox-2 y la mpges-1 en el cart\u00edlago articular de pacientes artr\u00f3sicos. La disminuci\u00f3n en la expresi\u00f3n y la s\u00edntesis de la inos podr\u00eda contribuir en la reducci\u00f3n de la progresi\u00f3n de la respuesta inflamatoria. Sin embargo, el cbx y el acf parecen tener un perfil antiinflamatorio diferente en cuanto al control de la presencia de citoquinas en el cart\u00edlago de pacientes con oa. tambi\u00e9n hemos demostrado, mediante estudios in vivo e in vitro, que hif-1\u00c2\u00bf y vegf podr\u00edan regularse por un mecanismo independiente de la pge2 durante la oa.  por \u00faltimo, hemos demostrado que en el cart\u00edlago de pacientes con artrosis, el tratamiento a largo plazo con cbx inhibe la se\u00f1al resortiva sintetizada por los condrocitos. In vitro, demostramos que la pge2 regula la expresi\u00f3n y la liberaci\u00f3n de los principales mediadores del metabolismo \u00f3seo en condrocitos artr\u00f3sicos. el planteamiento de este trabajo permite abrir nuevas hip\u00f3tesis en cuanto a la presencia de mecanismos dependientes e independientes de pge2 que podr\u00edan controlar la progresi\u00f3n de la oa.  osteoarthritis (oa) is the most common chronic joint disease. Joint cartilage degeneration is the central feature in oa, but is associated with concomitant changes in synovium and subchondral bone metabolism, causing pain and stiffness in the involved joints and an impaired physical function. Pge2 is a key mediator in the pathogenesis of oa. The most widespread agents employed for the control of oa symptoms are non-steroidal anti-inflammatory drugs (nsaid). The therapeutic efficacy of nsaid has been attributed to its ability to impair pge2 release by inhibiting cox enzyme activity. Although currently these drugs are employed over extended periods, their direct effects on cartilage are still to be fully defined.   this thesis demonstrates that prolonged therapy with pge2 blocking agents decreases pge2 production not only by direct inhibition of cox activity, but also by down-regulating cox-2 and mpges-1 expression and synthesis in the articular cartilage of oa patients. The down-regulation of inos in the articular cartilage would also contribute to reduce the progression of the inflammatory response. However, cbx and acf seem to have a different anti-inflammatory effect on cytokine synthesis both in the cartilage of oa patients.  we also demonstrated, by studies in vivo and in vitro, hif-1\u00c2\u00bf and vegf could be regulated by an independent mechanism of pge2 during the oa.   finally, we have shown that in cartilage from patients with oa, long-term nsaid treatment inhibited the resorptive signal synthesized by chondrocytes. In vitro, we showed that pge2 regulated the expression and release of these key mediators of bone metabolism by articular chondrocytes. this work opens new hypothesis for the mechanisms, both pge2 dependent and independent, which may control the progression of oa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de la inhibicion de la pge2 sobre la inflamacion y la sintesis de mediadores del metabolismo oseo en el cartilago articular de pacientes con artrosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de la inhibicion de la pge2 sobre la inflamacion y la sintesis de mediadores del metabolismo oseo en el cartilago articular de pacientes con artrosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Moreno Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/04\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Largo Carazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Arnalich fern\u00e1ndez <\/li>\n<li>Javier Rivera redondo (vocal)<\/li>\n<li>concepcion De la piedra gordo (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Lopez armada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Moreno Rubio La artrosis (oa) es la patolog\u00eda articular m\u00e1s frecuente. La caracter\u00edstica principal de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[204229,824,202315,204228,195979,96765],"class_list":["post-100225","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-concepcion-de-la-piedra-gordo","tag-francisco-arnalich-fernandez","tag-javier-rivera-redondo","tag-juan-moreno-rubio","tag-maria-jose-lopez-armada","tag-raquel-largo-carazo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100225","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=100225"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100225\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=100225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=100225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=100225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}