{"id":100654,"date":"2018-03-11T10:22:12","date_gmt":"2018-03-11T10:22:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-pravastatina-en-el-dano-miocardico-por-isquemia-y-reperfusion\/"},"modified":"2018-03-11T10:22:12","modified_gmt":"2018-03-11T10:22:12","slug":"papel-de-la-pravastatina-en-el-dano-miocardico-por-isquemia-y-reperfusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/papel-de-la-pravastatina-en-el-dano-miocardico-por-isquemia-y-reperfusion\/","title":{"rendered":"Papel de la pravastatina en el da\u00f1o mioc\u00e1rdico por isquemia y reperfusi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mario Casta\u00f1o Ruiz <\/strong><\/h2>\n<p>Introducci\u00f3n: la cirug\u00eda coronaria bajo circulaci\u00f3n extracorp\u00f3rea (cec) con pinzamiento  a\u00f3rtico induce da\u00f1o mioc\u00e1rdico por isquemia y reperfusi\u00f3n que puede ser mal tolerado en ciertos grupos de pacientes. La cec amplifica el da\u00f1o producido por el pinzamiento a\u00f3rtico a trav\u00e9s de la inducci\u00f3n de una intensa respuesta inflamatoria sist\u00e9mica.   objetivos: demostrar un beneficio cl\u00ednico y anal\u00edtico en el da\u00f1o mioc\u00e1rdico y la reacci\u00f3n inflamatoria sist\u00e9mica con la administraci\u00f3n de pravastatina en dosis \u00fanica oral previa a cirug\u00eda coronaria electiva bajo cec con pinzamiento a\u00f3rtico.  material y m\u00e9todos: se han incluido 20 pacientes candidatos a cirug\u00eda coronaria electiva de manera randomizada a los que se han administrado 80 mg de pravastatina por v\u00eda oral (grupo e, 10 pacientes) o placebo (grupo p, 10 pacientes) 2 horas previas a la inducci\u00f3n anest\u00e9sica. Se han recogido variables cl\u00ednicas referentes a morbimortalidad postoperatoria y se han determinado en sangre del seno coronario y venosa perif\u00e9rica intra y postoperatoriamente nf-b, citoquinas (tnf-, interfer\u00f3n-, il-10),  mol\u00e9culas de adhesi\u00f3n solubles, \u00f3xido n\u00edtrico, inos y radicales libres, as\u00ed como pcr, marcadores cl\u00ednicos de da\u00f1o mioc\u00e1rdico, de hepatotoxicidad y de rabdomiolis.   resultados: la pravastatina no induce variaciones en las variables cl\u00ednicas analizadas en cuanto a morbimortalidad. Tampoco produce efectos secundarios adversos. El f\u00e1rmaco no reduce de manera significativa la elevaci\u00f3n postoperatoria de marcadores de da\u00f1o mioc\u00e1rdico ni los eventos cl\u00ednicos cardiacos aunque amortigua de manera significativa la reacci\u00f3n inflamatoria producida por la cec.  conclusiones: la pravastatina administrada a dosis terap\u00e9uticas en monodosis previamente a la cirug\u00eda coronaria reduce de manera significativa la reacci\u00f3n inflamatoria sist\u00e9mica inducida por la cec, aunque ello no se traduce en una reducci\u00f3n de los marcadores de da\u00f1o mioc\u00e1rdico ni de los eventos cl\u00ednicos adversos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la pravastatina en el da\u00f1o mioc\u00e1rdico por isquemia y reperfusi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la pravastatina en el da\u00f1o mioc\u00e1rdico por isquemia y reperfusi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mario Casta\u00f1o Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/04\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Gomez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Garcia criado <\/li>\n<li>Jos\u00e9 Rubio \u00e1lvarez (vocal)<\/li>\n<li>Santiago Florez pelaez (vocal)<\/li>\n<li>sara Benedito castellote (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mario Casta\u00f1o Ruiz Introducci\u00f3n: la cirug\u00eda coronaria bajo circulaci\u00f3n extracorp\u00f3rea (cec) con pinzamiento a\u00f3rtico induce da\u00f1o mioc\u00e1rdico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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