{"id":100663,"date":"2010-03-05T00:00:00","date_gmt":"2010-03-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pirazino-12-b-isoquinolinas-sa%c2%adntesis-manipulacion-estructural-y-actividad-biologica\/"},"modified":"2010-03-05T00:00:00","modified_gmt":"2010-03-05T00:00:00","slug":"pirazino-12-b-isoquinolinas-sa%c2%adntesis-manipulacion-estructural-y-actividad-biologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pirazino-12-b-isoquinolinas-sa%c2%adntesis-manipulacion-estructural-y-actividad-biologica\/","title":{"rendered":"Pirazino (1,2-b) isoquinolinas. s\u00edntesis, manipulaci\u00f3n estructural y actividad biol\u00f3gica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Eloisa Ortin Remon <\/strong><\/h2>\n<p>En este trabajo hemos desarrollado una nueva estrategia sint\u00e9tica para la obtenci\u00f3n de an\u00e1logos estructurales de la familia de antibi\u00f3ticos con estructura tetrahidroisoquinol\u00ednica. Adem\u00e1s se ha realizado el estudio de actividad biol\u00f3gica en tres l\u00edne as celulares (mama mda-mb-231, pulm\u00f3n a549 y colon ht29) de los compuestos sintetizados. Tambi\u00e9n mostramos un estudio detallado del mecanismo de acci\u00f3n del compuesto que present\u00f3 mayor actividad antitumoral ((6r*,11as*)-6-benciloximetil-2-isopropilox icarbonil-9-metil-7,8,10-trimetoxi-1,2,3,6,11,11a-hexahidro-pirazino[1,2-b]isoquinolin-4-ona).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Pirazino (1,2-b) isoquinolinas. s\u00edntesis, manipulaci\u00f3n estructural y actividad biol\u00f3gica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Pirazino (1,2-b) isoquinolinas. s\u00edntesis, manipulaci\u00f3n estructural y actividad biol\u00f3gica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Eloisa Ortin Remon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Avenda\u00f1o L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide ala\u00f1on <\/li>\n<li>a. Ganesan (vocal)<\/li>\n<li>esther Dominguez perez (vocal)<\/li>\n<li>Andr\u00e9s m. Francesch solloso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Eloisa Ortin Remon En este trabajo hemos desarrollado una nueva estrategia sint\u00e9tica para la obtenci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[204915,204916,5891,21276,204914,17715],"class_list":["post-100663","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-a-ganesan","tag-andres-m-francesch-solloso","tag-benito-alcaide-alanon","tag-esther-dominguez-perez","tag-irene-eloisa-ortin-remon","tag-maria-del-carmen-avendano-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=100663"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100663\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=100663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=100663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=100663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}