{"id":100693,"date":"2010-05-05T00:00:00","date_gmt":"2010-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-antigenica-y-patogenica-del-virus-del-sa%c2%adndrome-reproductor-y-respiratorio-porcino\/"},"modified":"2010-05-05T00:00:00","modified_gmt":"2010-05-05T00:00:00","slug":"variabilidad-antigenica-y-patogenica-del-virus-del-sa%c2%adndrome-reproductor-y-respiratorio-porcino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-antigenica-y-patogenica-del-virus-del-sa%c2%adndrome-reproductor-y-respiratorio-porcino\/","title":{"rendered":"Variabilidad antig\u00e9nica y patog\u00e9nica del virus del s\u00edndrome reproductor y respiratorio porcino."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Martinez Lobo <\/strong><\/h2>\n<p>Debido a la enorme variabilidad gen\u00f3mica, antig\u00e9nica y patog\u00e9nica del virus del s\u00edndrome reproductor y respiratorio porcino (vsrrp), el objetivo fundamental de la tesis doctoral ha sido la caracterizaci\u00f3n antig\u00e9nica y patog\u00e9nica de aislados del vsrrp , y especialmente, y debido a la falta de informaci\u00f3n relativa a los mismos, de aislados de tipo i. Para ello, se realiz\u00f3 la caracterizaci\u00f3n antig\u00e9nica de los aislados del vsrrp y espec\u00edficamente de aislados de distinto origen de genotipo i mediante ensayos de sn cruzada, y se llev\u00f3 a cabo un estudio sobre la patogenicidad de aislados del vsrrp de distintos or\u00edgenes, con especial \u00e9nfasis en el genotipo i, en el modelo respiratorio.  el estudio detallado de las relaciones antig\u00e9nicas medidas medi ante ensayos de sn entre los aislados del vsrrp determin\u00f3 que no es posible una clasificaci\u00f3n o agrupamiento razonable de los mismos en serogrupos, siendo dicha similitud antig\u00e9nica independiente del lugar de aislamiento y del momento de circulaci\u00f3n de dichos aislados. Estos hallazgos no se correlacionaron ni con la relaci\u00f3n filogen\u00e9tica entre aislados, ni con la secuencia aminoac\u00eddica del ep\u00edtopo neutralizante ni con los sitios potenciales de n-glicosilaci\u00f3n de la gp5.  los resultados obtenidos  a lo largo de este estudio demuestran que los aislados del vsrrp de genotipo europeo difieren en su virulencia en el modelo respiratorio de la enfermedad. Es m\u00e1s, se ha demostrado la existencia de aislados de alta y baja virulencia dentro de este ge notipo. Estas diferencias en patogenicidad no se asociaron de manera espec\u00edfica a ning\u00fan factor geogr\u00e1fico o temporal de los aislados del vsrrp. Sin embargo, la virulencia de los aislados europeos del vsrrp se corresponde con carga v\u00edrica en suero y en algunos tejidos, por lo que la capacidad replicativa ser\u00eda un factor de virulencia de dichos aislados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad antig\u00e9nica y patog\u00e9nica del virus del s\u00edndrome reproductor y respiratorio porcino.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad antig\u00e9nica y patog\u00e9nica del virus del s\u00edndrome reproductor y respiratorio porcino. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Martinez Lobo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Castro Arganda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Miguel Ortega mora <\/li>\n<li>Juan  anselmo Perea remujo (vocal)<\/li>\n<li>pedro Miguel Rubio nistal (vocal)<\/li>\n<li>Antonio  Jos\u00e9 Arenas casas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Martinez Lobo Debido a la enorme variabilidad gen\u00f3mica, antig\u00e9nica y patog\u00e9nica del virus del s\u00edndrome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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