{"id":10070,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/sintones-piperidinicos-homoquirales-utilizacion-en-la-sintesis-de-alcaloides-en-forma-enantiopura\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"sintones-piperidinicos-homoquirales-utilizacion-en-la-sintesis-de-alcaloides-en-forma-enantiopura","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintones-piperidinicos-homoquirales-utilizacion-en-la-sintesis-de-alcaloides-en-forma-enantiopura\/","title":{"rendered":"Sintones piperidinicos homoquirales. utilizacion en la sintesis de alcaloides en forma enantiopura."},"content":{"rendered":"<h2>Tesis doctoral de <strong> N\u00faria Llor Brun\u00e9s <\/strong><\/h2>\n<p>Las oxazolopiperidonas 1,2 y 3 pueden prepararse satisfactoriamente por formacion de las correspondientes imidas a partir del anhidrido glutarico y los aminoalcoholes homoquirales fenilglicinol y valinol seguido de reduccion parcial en medio acido en los casos 1 y 2 o por ciclodeshidratacion entre el 5-oxopentanoato de metilo y los aminoalcoholes adecuados en los casos de 1, 2 y 3. Se ha demostrado la utilidad de la oxazolopiperidona la como precursora en la sintesis de derivados de la piperidina en forma enantiopura. Asi, se han sintetizado 2-alquilpiperidinas, coniina, 2,6- dialquil piperidinas (dihidropinidina) y 3-alquilpiperidinas. Se ha establecido un procedimiento para la preparacion de 6-(2-piperidil) indoles homoquirales, poniendose de manifiesto que la facil epimerizacion (o raecemizacion) que experimentan dichos sistemas puede evitarse bloqueando el nitrogeno indolico con un grupo atrayente de electrones.  finalmente, se han realizado estudios de adicion conjugada sobre la lactama 61, obteniendose de forma satisfactoria las 6-(3-indolil)-2-piperidonas sustituidas en posicion 4. Se ha estudiado la utilidad de estos derivados en la construccion del sistema tetraciclico abde caracteristico de los alcaloides strychnos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintones piperidinicos homoquirales. utilizacion en la sintesis de alcaloides en forma enantiopura.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintones piperidinicos homoquirales. utilizacion en la sintesis de alcaloides en forma enantiopura. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 N\u00faria Llor Brun\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Bosch Cartes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Garc\u00eda Ruano <\/li>\n<li>Pere De March Centelles (vocal)<\/li>\n<li>Francisco Palacios Gambra (vocal)<\/li>\n<li>Sergio Castillon Miranda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de N\u00faria Llor Brun\u00e9s Las oxazolopiperidonas 1,2 y 3 pueden prepararse satisfactoriamente por formacion de las correspondientes imidas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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