{"id":100723,"date":"2010-06-05T00:00:00","date_gmt":"2010-06-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-moleculares-en-sangre-de-pacientes-con-primeros-episodios-psicoticos\/"},"modified":"2010-06-05T00:00:00","modified_gmt":"2010-06-05T00:00:00","slug":"alteraciones-moleculares-en-sangre-de-pacientes-con-primeros-episodios-psicoticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/alteraciones-moleculares-en-sangre-de-pacientes-con-primeros-episodios-psicoticos\/","title":{"rendered":"Alteraciones moleculares en sangre de pacientes con primeros episodios psic\u00f3ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aitor Palomino Fernandez De Larrea <\/strong><\/h2>\n<p>La esquizofrenia es un tipo de psicosis heredable que afecta aproximadamente al 1% de la poblaci\u00f3n. Los enfermos sufren d\u00e9ficits tanto en las funciones cognitivas como en las emocionales. El rasgo m\u00e1s caracter\u00edstico del trastorno bipolar son los episodios de man\u00eda o hipoman\u00eda intercalados con per\u00edodos de depresi\u00f3n. Comprender la etiolog\u00eda y patog\u00e9nesis de la esquizofrenia y el trastorno bipolar es uno de los mayores retos a los que se enfrenta la psiquiatr\u00eda. entre las diferentes hip\u00f3tesis que se postulan, una de las m\u00e1s importantes implica al sistema glutamat\u00e9rgico. De hecho, se han observado alteraciones en la se\u00f1alizaci\u00f3n glutamat\u00e9rgica en la esquizofrenia a nivel de la maquinaria de liberaci\u00f3n presin\u00e1ptica y de receptores del \u00e1cido glut\u00e1mico. Otra hip\u00f3tesis se basa en el mal funcionamiento de los factores neurotr\u00f3ficos que podr\u00eda provocar alteraciones en el desarrollo del cerebro y en la plasticidad en la edad adulta. Existen otras hip\u00f3tesis como la dopamin\u00e9rgica, la inmune o la gaba\u00e9rgica. en este proyecto de tesis nos hemos basado en varias de estas hip\u00f3tesis para analizar sangre de pacientes con los primeros s\u00edntomas de las enfermedades, haci\u00e9ndose un seguimiento longitudinal de dichos niveles al mes, seis meses y un a\u00f1o de su tratamiento. En concreto, hemos estudiado los niveles en plasma de la neurotrofina bdnf, de igf-1, de la citoquina tnf\u00c2\u00bf y del neurotransmisor glutamato y los hemos comparado con los niveles en controles emparejados por edad y sexo. adicionalmente, se ha profundizado en la relaci\u00f3n del neurotransmisor glutamato con las enfermedades psiqui\u00e1tricas con un estudio de polimorfismos de los genes implicados en la el funcionamiento de la neurotransmisi\u00f3n glutamat\u00e9rgica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones moleculares en sangre de pacientes con primeros episodios psic\u00f3ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones moleculares en sangre de pacientes con primeros episodios psic\u00f3ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aitor Palomino Fernandez De Larrea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Matute Almau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Mic\u00f3 segura <\/li>\n<li>Jos\u00e9 Luis Carrasco perera (vocal)<\/li>\n<li>Jos\u00e9 Borrell andres (vocal)<\/li>\n<li>celso Arango lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aitor Palomino Fernandez De Larrea La esquizofrenia es un tipo de psicosis heredable que afecta aproximadamente al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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