{"id":100861,"date":"2018-03-11T10:22:30","date_gmt":"2018-03-11T10:22:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-estrategias-diagnosticas-basadas-en-la-capacidad-metabolizante-de-la-piel-y-del-papel-de-las-celulas-dendra%c2%adticas-en-la-induccion-de-reacciones-alergicas-frente-a-farmacos\/"},"modified":"2018-03-11T10:22:30","modified_gmt":"2018-03-11T10:22:30","slug":"desarrollo-de-estrategias-diagnosticas-basadas-en-la-capacidad-metabolizante-de-la-piel-y-del-papel-de-las-celulas-dendra%c2%adticas-en-la-induccion-de-reacciones-alergicas-frente-a-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neuropatologia\/desarrollo-de-estrategias-diagnosticas-basadas-en-la-capacidad-metabolizante-de-la-piel-y-del-papel-de-las-celulas-dendra%c2%adticas-en-la-induccion-de-reacciones-alergicas-frente-a-farmacos\/","title":{"rendered":"Desarrollo de estrategias diagn\u00f3sticas basadas en la capacidad metabolizante de la piel, y del papel de las c\u00e9lulas dendr\u00edticas en la inducci\u00f3n de reacciones al\u00e9rgicas frente a f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Gomez Alcaide <\/strong><\/h2>\n<p>T\u00edtulo de la tesis: desarrollo de estrategias diagn\u00f3sticas basadas en la capacidad metabolizante de la piel, y del papel de las c\u00e9lulas dendr\u00edticas en la inducci\u00f3n de reacciones al\u00e9rgicas frente a f\u00e1rmacos. resumen: esta tesis doctoral se plante\u00f3 con el objetivo de conocer en mayor profundidad los mecanismos implicados en las reacciones no inmediatas mediadas por c\u00e9lulas t con afecci\u00f3n cut\u00e1nea, frente a f\u00e1rmacos que requieren ser biotransformados, as\u00ed como conocer el papel de las c\u00e9lulas dendr\u00edticas, componentes del sistema inmunol\u00f3gico, en la generaci\u00f3n de dichas respuestas. para ello se han desarrollado diferentes metodolog\u00edas que abarcan tanto diferentes t\u00e9cnicas moleculares como cultivos celulares y estudios de citometr\u00eda de flujo. Se ha estudiado el perfil de expresi\u00f3n del citocromo p450 en diferentes subpoblaciones y se ha relacionado con la actividad metab\u00f3lica desarrollada. A su vez, se propone una nueva versi\u00f3n del test de transformaci\u00f3n linfocitaria que mejorana el diagnostico in vitro de este tipo de reacciones. los resultados otorgan a la piel una capacidad para la actividad biotransformadora. Adem\u00e1s, se demostr\u00f3 un cambio en la expresi\u00f3n y actividad de las c\u00e9lulas dendr\u00edticas a lo largo del proceso de diferenciaci\u00f3n y maduraci\u00f3n. El test de transformaci\u00f3n linfocitaria con la inclusi\u00f3n de una l\u00ednea celular con capacidad para el metabolismo de f\u00e1rmacos, mostr\u00f3 una mejora en la capacidad diagn\u00f3stica del mismo, abriendo un camino a la investigaci\u00f3n in vitro de este tipo de reacciones celulares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de estrategias diagn\u00f3sticas basadas en la capacidad metabolizante de la piel, y del papel de las c\u00e9lulas dendr\u00edticas en la inducci\u00f3n de reacciones al\u00e9rgicas frente a f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de estrategias diagn\u00f3sticas basadas en la capacidad metabolizante de la piel, y del papel de las c\u00e9lulas dendr\u00edticas en la inducci\u00f3n de reacciones al\u00e9rgicas frente a f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Gomez Alcaide <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Blanca G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m isabel Lucena gonzalez <\/li>\n<li>Mar\u00eda Jos\u00e9 Torres ja\u00e9n (vocal)<\/li>\n<li>Mar\u00eda  gabriela Canto diez (vocal)<\/li>\n<li>Jos\u00e9 augusto Garc\u00eda-ag\u00fandez p\u00e9rez-coca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Gomez Alcaide T\u00edtulo de la tesis: desarrollo de estrategias diagn\u00f3sticas basadas en la capacidad metabolizante de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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