{"id":100930,"date":"2018-03-11T10:22:34","date_gmt":"2018-03-11T10:22:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-interacciones-en-la-transicion-epitelio-mesenquima-la-quinasa-akt-como-efector-del-factor-transcripcional-snail1\/"},"modified":"2018-03-11T10:22:34","modified_gmt":"2018-03-11T10:22:34","slug":"nuevas-interacciones-en-la-transicion-epitelio-mesenquima-la-quinasa-akt-como-efector-del-factor-transcripcional-snail1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/nuevas-interacciones-en-la-transicion-epitelio-mesenquima-la-quinasa-akt-como-efector-del-factor-transcripcional-snail1\/","title":{"rendered":"Nuevas interacciones en la transici\u00f3n epitelio mes\u00e9nquima: la quinasa akt como efector del factor transcripcional snail1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Villagrasa Gonzalez <\/strong><\/h2>\n<p>La transici\u00f3n epitelio mes\u00e9nquima (emt) es un proceso biol\u00f3gico que permite que las c\u00e9lulas cambien de un fenotipo polarizado y epitelial a uno altamente motriz y fibroblastoide.  La emt tiene lugar durante el desarrollo embrionario y en la reparaci\u00f3n tisular. En contraste, la emt puede causar situaciones patol\u00f3gicas como la fibrosis y pomover la prograsi\u00f3n tumoral.  snail1 es un factor de transcripci\u00f3n que juega un papel importante en dicho proceso. Este papel es debido a que es uno de los represores del gen que codifica para la e-cadherina, prote\u00edna que forma parte de las uniones ce\u00e9lula-c\u00e9lula, esencial para mantener la integridad y polaridad de las c\u00e9lulas que forman los epitelios. la serina\/treonina quinasa akt\/pkb, a parte de ser una quinasa multifuncional ya que regula una gran variedad de procesos celulares, ha sido descrita recientemente c\u00f3mo uno de los inductores de la emt. en este trabajo nos hemos centrado en la caracterizaci\u00f3n de la relaci\u00f3n entre snail1 y akt dentro del contexto de la emt en c\u00e9lulas tumorales. Hemos estudiado la contribuci\u00f3n de las isoformas de akt, akt1 y akt2, en los cambios moleculares inducidos por la expresi\u00f3n de snail1 siendo \u00e9sta diferente dependiendo de la l\u00ednea celular analizada. Adem\u00e1s, describimos un nuevo mecanismo, mediante el cual snail1 activa a akt, asociado a la interacci\u00f3n entre ambas prote\u00ednas. Hemos identificado a akt2 c\u00f3mo la isoforma de akt que interacciona con snail1 en c\u00e9lulas tumorales. Por tanto, nuestro estudio propone una nueva funci\u00f3n de snail1, no descrita anteriormente: la de cofactor directo de la quinasa akt2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas interacciones en la transici\u00f3n epitelio mes\u00e9nquima: la quinasa akt como efector del factor transcripcional snail1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas interacciones en la transici\u00f3n epitelio mes\u00e9nquima: la quinasa akt como efector del factor transcripcional snail1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Villagrasa Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garcia De Herreros Madue\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zorzano olarte <\/li>\n<li>isabel Puig borrell (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Villagrasa Gonzalez La transici\u00f3n epitelio mes\u00e9nquima (emt) es un proceso biol\u00f3gico que permite que las c\u00e9lulas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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