{"id":100952,"date":"2018-03-11T10:22:34","date_gmt":"2018-03-11T10:22:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-modificaciones-proteicas-en-el-plasma-y-plaquetas-en-pacientes-resistentes-a-aspirina-con-enfermedad-coronaria-establecida\/"},"modified":"2018-03-11T10:22:34","modified_gmt":"2018-03-11T10:22:34","slug":"identificacion-de-modificaciones-proteicas-en-el-plasma-y-plaquetas-en-pacientes-resistentes-a-aspirina-con-enfermedad-coronaria-establecida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-modificaciones-proteicas-en-el-plasma-y-plaquetas-en-pacientes-resistentes-a-aspirina-con-enfermedad-coronaria-establecida\/","title":{"rendered":"Identificaci\u00f3n de modificaciones prot\u00e9icas en el plasma y plaquetas en pacientes resistentes a aspirina con enfermedad coronaria establecida."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jorge Gonzalez Armengol <\/strong><\/h2>\n<p>1.\tIntroducci\u00f3n  1.1\taterotrombosis  la trombosis coronaria es la causa m\u00e1s frecuente de morbimortalidad y la manifestaci\u00f3n mas grave de la aterosclerosis. Los mecanismos de formaci\u00f3n del trombo sobre una placa ateroscler\u00f3tica son complejos en los \u00fal timos a\u00f1os, ha comenzado a considerarse la importancia del componente inflamatorio en la patogenia de la rotura del ateroma.   1.2\tmecanismos de activaci\u00f3n plaquetaria              la adhesi\u00f3n de las plaquetas al subendotelio, su agregaci\u00f3n y recluta miento, propicia la formaci\u00f3n de un trombo. En los \u00faltimos a\u00f1os, se ha demostrado que la trombosis vascular es  un proceso en que intervienen m\u00faltiples c\u00e9lulas, como las del endotelio vascular y los neutr\u00f3filos. 1.2.1. La plaqueta las plaquetas son f ragmentos anucleares derivados de los megacariocitos de la m\u00e9dula \u00f3sea . La producci\u00f3n de plaquetas desde la  m\u00e9dula \u00f3sea a megacariocitos est\u00e1 regulada por la trombopoyetina, que parece tener un papel importante en la reversi\u00f3n de la trombocitopenia .  1.2.2. Composici\u00f3n plaquetaria 1.2.2.1 glicoprote\u00ednas plaquetarias 1.2.2.1.1. Glicoprote\u00edna plaquetaria ib 1.2.2.1.2. Glicoprote\u00edna plaquetaria iib-iiia 1.2.2.1.3 glicoprote\u00edna plaquetaria ia-iia 1.2.2.2 zona de organelos 1.2.3. Activaci\u00f3n plaquet aria a la hora de estudiar la funci\u00f3n plaquetaria podemos diferenciar varias fases aunque realmente todas ellas se producen simult\u00e1neamente en el tiempo. Primero cambian de forma y se convierten en adhesivas y a continuaci\u00f3n (en presencia de calcio y  fibrin\u00f3geno), se agregan y finalmente liberan el contenido de sus diferentes gr\u00e1nulos de almacenamiento. 1.2.3.1. Agonistas de la activaci\u00f3n plaquetaria  1.2.3.1.1. Adp (adenos\u00edn difosfato) 1.2.3.1.2. Ionosfera de calcio 1.2.3.1.3. Col\u00e1geno 1.2.3.1. 4. Trombina 1.2.3.1.5. Adrenalina 1.2.3.2. Fases de activaci\u00f3n plaquetaria  podemos hablar de las siguientes fases de  activaci\u00f3n plaquetaria: cambio de morfolog\u00eda, adhesi\u00f3n, agregaci\u00f3n y secreci\u00f3n. 1.2.4. Interacci\u00f3n entre plaquetas y las c\u00e9lulas de l microentorno vascular. las plaquetas por s\u00ed mismas no tienen actividad proinflamatoria cuando alcanzan los sitios de las fisuras o las placas ateroscler\u00f3ticas rotas, sin embargo, s\u00ed son proinflamatorias con los neutr\u00f3filos a trav\u00e9s del metabolismo transcelular.   1.3\ttratamiento antiplaquetario: la aspirina. 1.3.1. Breve historia de la aspirina.  en 1897, el qu\u00edmico alem\u00e1n felix hoffmann (figura 9), que trabajaba para la compa\u00f1\u00eda alemana bayer,  a\u00edsla \u00e1cido acetilsalic\u00edlico. 1.3.2. Farmacocin\u00e9<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de modificaciones prot\u00e9icas en el plasma y plaquetas en pacientes resistentes a aspirina con enfermedad coronaria establecida.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de modificaciones prot\u00e9icas en el plasma y plaquetas en pacientes resistentes a aspirina con enfermedad coronaria establecida. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jorge Gonzalez Armengol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Barrientos guzm\u00e1n <\/li>\n<li>Juan  Carlos Porres cubero (vocal)<\/li>\n<li>Luis alfonso Rico  zalba (vocal)<\/li>\n<li>Juan  Mar\u00eda Gonzalez del castillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jorge Gonzalez Armengol 1. Introducci\u00f3n 1.1 aterotrombosis la trombosis coronaria es la causa m\u00e1s frecuente de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[78089,14976,147637,205384,147636,59823],"class_list":["post-100952","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alberto-barrientos-guzman","tag-antonio-lopez-farre","tag-juan-carlos-porres-cubero","tag-juan-jorge-gonzalez-armengol","tag-juan-maria-gonzalez-del-castillo","tag-luis-alfonso-rico-zalba"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=100952"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/100952\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=100952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=100952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=100952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}