{"id":101098,"date":"2018-03-11T10:22:47","date_gmt":"2018-03-11T10:22:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-canales-ionicos-de-calcio-dependientes-de-voltaje-en-la-modulacion-de-las-senales-nociceptivas-en-la-medula-espinal\/"},"modified":"2018-03-11T10:22:47","modified_gmt":"2018-03-11T10:22:47","slug":"papel-de-los-canales-ionicos-de-calcio-dependientes-de-voltaje-en-la-modulacion-de-las-senales-nociceptivas-en-la-medula-espinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/papel-de-los-canales-ionicos-de-calcio-dependientes-de-voltaje-en-la-modulacion-de-las-senales-nociceptivas-en-la-medula-espinal\/","title":{"rendered":"Papel de los canales i\u00f3nicos de calcio dependientes de voltaje en la modulaci\u00f3n de las se\u00f1ales nociceptivas en la m\u00e9dula espinal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Mart\u00ednez G\u00f3mez <\/strong><\/h2>\n<p>El objetivo de este trabajo consisti\u00f3 en establecer una preparaci\u00f3n experimental de m\u00e9dula de rat\u00f3n in vitro para estudiar, de forma simult\u00e1nea, informaci\u00f3n motora (mediante registros en ra\u00edz ventral) e informaci\u00f3n sensorial (mediante registro de axones ascendente) evocada por  estimulaci\u00f3n el\u00e9ctrica de bajo y alto umbral (o nociceptiva) de la entradas aferentes. De esta manera, y mediante el uso de diferentes f\u00e1rmacos se trat\u00f3 de establecer similitudes y diferencias entre ambos tipos de procesamiento (motor vs sensorial) en m\u00e9dula espinal. Para ello se estudi\u00f3 la modulaci\u00f3n de la informaci\u00f3n sensorial y motora por un gas anest\u00e9sico (sevoflurano) y por una amina bi\u00f3gena (noradrenalina) as\u00ed como el papel de los canales de calcio dependientes de voltage (ccdv). el sevoflurano deprimi\u00f3 la transmisi\u00f3n por ambas v\u00edas mientras que la noradrenalina deprimi\u00f3 la v\u00eda sensorial y potenci\u00f3 la v\u00eda motora. La aplicaci\u00f3n de diferentes antagonistas de los (cdv, (verapamil, diltiazem y nimodipina), dificult\u00f3 la capacidad de las v\u00edas motoras para producir descargas sostenidas en respuesta a la activaci\u00f3n sin\u00e1ptica repetitiva; sin embargo tuvo efectos mucho m\u00e1s modestos en las v\u00edas sensoriales ascendentes. Por otra parte, la aplicaci\u00f3n del agonista de los ccdv de tipo l bay k8644 aument\u00f3 considerablemente la actividad de los circuitos motores medulares, sin afectar, aparentemente, la informaci\u00f3n sensorial ascendente. este modelo experimental demuestra que es posible estudiar de modo simult\u00e1neo el efecto de diferentes f\u00e1rmacos sobre la regulaci\u00f3n de los circuitos espinales motores y sensoriales en respuesta a estimulaci\u00f3n nociceptiva y no nociceptiva.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los canales i\u00f3nicos de calcio dependientes de voltaje en la modulaci\u00f3n de las se\u00f1ales nociceptivas en la m\u00e9dula espinal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los canales i\u00f3nicos de calcio dependientes de voltaje en la modulaci\u00f3n de las se\u00f1ales nociceptivas en la m\u00e9dula espinal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Mart\u00ednez G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio L\u00f3pez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Cerver\u00f3 Santiago <\/li>\n<li>Juan  reyes Aguilar lepe (vocal)<\/li>\n<li>cruz Miguel Cend\u00e1n mart\u00ednez (vocal)<\/li>\n<li>pedro De  la villa polo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Mart\u00ednez G\u00f3mez El objetivo de este trabajo consisti\u00f3 en establecer una preparaci\u00f3n experimental de m\u00e9dula de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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