{"id":101139,"date":"2018-03-11T10:22:47","date_gmt":"2018-03-11T10:22:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-genica-diferencial-de-la-via-wnt-y-de-moleculas-de-adhesion-y-matriz-extracelular-en-cancer-colorrectal-esporadico-con-y-sin-inestabilidad-en-microsatelites\/"},"modified":"2018-03-11T10:22:47","modified_gmt":"2018-03-11T10:22:47","slug":"expresion-genica-diferencial-de-la-via-wnt-y-de-moleculas-de-adhesion-y-matriz-extracelular-en-cancer-colorrectal-esporadico-con-y-sin-inestabilidad-en-microsatelites","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-genica-diferencial-de-la-via-wnt-y-de-moleculas-de-adhesion-y-matriz-extracelular-en-cancer-colorrectal-esporadico-con-y-sin-inestabilidad-en-microsatelites\/","title":{"rendered":"Expresi\u00f3n g\u00e9nica diferencial de la via wnt y de mol\u00e9culas de adhesi\u00f3n y matriz extracelular en c\u00e1ncer colorrectal espor\u00e1dico con y sin inestabilidad en microsat\u00e9lites"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Ortega Esteban <\/strong><\/h2>\n<p>El trabajo desarrollado en esta tesis se centra en c\u00e1nceres colorrectales espor\u00e1dicos, estudiando las posibles diferencias moleculares entre las dos v\u00edas tumorog\u00e9nicas: supresora y del fenotipo mutador. La primera se desarrolla por alteraciones en ge nes supresores de tumores y oncogenes t\u00edpicos, y la segunda por alteraciones en genes de reparaci\u00f3n del adn del mismatchrepair. La v\u00eda wnt es una cascada proliferativa que regula la homeostasis del epitelio intestinal. Tiene un alto porcentaje de alt eraciones en tumores colorrectales. Es por ello, que en este trabajo, se desarroll\u00f3 un estudio de expresi\u00f3n con membranas de oligonucle\u00f3tidos en relaci\u00f3n con esta v\u00eda proliferativa. Los genes ppp2r1b, csn1d, tle3, dvl2, kremen2, fbxw4 mostraron menor  expresi\u00f3n en tumores msi-l\/mss frente a tumores msi-h. En cambio el gen wif1 se expres\u00f3 menos en tumores msi-h frente a tumores msi-l\/mss. Posteriormente se confirm\u00f3 en l\u00edneas celulares msi-h que el gen fbxw4 es un regulador negativo de la cascada, mientras que dvl2 y ppp2r1b son reguladores positivos. Por otro lado, se desarroll\u00f3 otro estudio de expresi\u00f3n con membranas de oligonucle\u00f3tidos para mol\u00e9culas de adhesi\u00f3n y matriz extracelular en los mismos tipos tumorales. Los resultados mostraron d iferencias significativas para los genes mmp-7 y sgce, ambos expresados en mayor medida en tumores msi-l\/mss frente a tumores msi-h, siendo adem\u00e1s mmp-7 diana de la v\u00eda wnt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n g\u00e9nica diferencial de la via wnt y de mol\u00e9culas de adhesi\u00f3n y matriz extracelular en c\u00e1ncer colorrectal espor\u00e1dico con y sin inestabilidad en microsat\u00e9lites<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n g\u00e9nica diferencial de la via wnt y de mol\u00e9culas de adhesi\u00f3n y matriz extracelular en c\u00e1ncer colorrectal espor\u00e1dico con y sin inestabilidad en microsat\u00e9lites <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Ortega Esteban <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Roman Benito De Las Heras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>alfredo Carrato mena (vocal)<\/li>\n<li>trinidad Cald\u00e9s llopis (vocal)<\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Ortega Esteban El trabajo desarrollado en esta tesis se centra en c\u00e1nceres colorrectales espor\u00e1dicos, estudiando las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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