{"id":101299,"date":"2010-01-06T00:00:00","date_gmt":"2010-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-metilacion-de-los-micrornas-en-la-en-la-patogenesis-y-pronostico-de-la-leucemia-linfoblastica\/"},"modified":"2010-01-06T00:00:00","modified_gmt":"2010-01-06T00:00:00","slug":"papel-de-la-metilacion-de-los-micrornas-en-la-en-la-patogenesis-y-pronostico-de-la-leucemia-linfoblastica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hemopatologia\/papel-de-la-metilacion-de-los-micrornas-en-la-en-la-patogenesis-y-pronostico-de-la-leucemia-linfoblastica\/","title":{"rendered":"Papel de la metilacion de los micrornas en la en la patogenesis y pronostico de la leucemia linfoblastica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victor Arqueros Martinez <\/strong><\/h2>\n<p>Los micrornas (mirnas), forman una familia de aproximadamente 300 rnas no codificantes de cadena simple y corta (\u00c2\u00bf22 nucle\u00f3tidos), que regulan negativamente la expresi\u00f3n de genes diana a nivel post-transcripcional, bien degradando directamente el rnam o bien inhibiendo la traducci\u00f3n del rnam diana a su prote\u00edna. Los patrones de expresi\u00f3n de estos mirnas juegan papeles cruciales en la proliferaci\u00f3n, diferenciaci\u00f3n y apoptosis celular y parecen estar involucrados en los procesos de oncog\u00e9nesis. En este sentido, la disminuci\u00f3n en la expresi\u00f3n de mirnas es un hallazgo com\u00fan en las neoplasias sugiriendo que estos mirnas act\u00faan como genes supresores de tumores. Sin embargo, el papel que desempe\u00f1an en la leucemia aguda linfobl\u00e1stica (lal) permanece por dilucidar. Aunque una posible explicaci\u00f3n de la falta de expresi\u00f3n de mirnas en los tumores puede ser debida a un fallo en la regulaci\u00f3n post-transcripcional de los mismos, otros mecanismos tambi\u00e9n pueden estar implicados. Debido a que uno de los principales mecanismos de silencio transcripcional de genes supresores de tumores cl\u00e1sicos en la lal es la hipermetilaci\u00f3n de islas cpg situadas en los promotores, cabe la posibilidad de que este mismo evento epigen\u00e9tico tambi\u00e9n est\u00e9 implicado en las alteraciones de mirnas observadas en las neoplasias humanas. Para explorar esta hip\u00f3tesis compararemos el patr\u00f3n de expresi\u00f3n de mirnas en l\u00edneas de lal v\u00edrgenes y tras ser tratadas con agentes desmetilantes mediante un microarray de expresi\u00f3n de mirnas. Adem\u00e1s, los resultados obtenidos se verificar\u00e1n en una cohorte de 390 pacientes diagnosticados de novo de lal mediante pcr espec\u00edfica de metilaci\u00f3n, secuenciaci\u00f3n y an\u00e1lisis de expresi\u00f3n por pcr cuantitativa en tiempo real con el fin de conocer el papel que juega la metilaci\u00f3n de mirnas en el desarrollo, progresi\u00f3n y pron\u00f3stico de esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la metilacion de los micrornas en la en la patogenesis y pronostico de la leucemia linfoblastica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la metilacion de los micrornas en la en la patogenesis y pronostico de la leucemia linfoblastica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victor Arqueros Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Rom\u00e1n G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Sierra gil <\/li>\n<li>Jos\u00e9 Francisco Tomas Martinez (vocal)<\/li>\n<li>vanesa Martin palanco (vocal)<\/li>\n<li>Jos\u00e9 Lopez miranda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victor Arqueros Martinez Los micrornas (mirnas), forman una familia de aproximadamente 300 rnas no codificantes de cadena [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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