{"id":101357,"date":"2010-04-06T00:00:00","date_gmt":"2010-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/signalling-of-cyclin-o-complexes-through-eif2alpha-phosphorylation\/"},"modified":"2010-04-06T00:00:00","modified_gmt":"2010-04-06T00:00:00","slug":"signalling-of-cyclin-o-complexes-through-eif2alpha-phosphorylation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/signalling-of-cyclin-o-complexes-through-eif2alpha-phosphorylation\/","title":{"rendered":"Signalling of cyclin o complexes through eif2alpha phosphorylation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Ortet Cortada <\/strong><\/h2>\n<p>Hemos identificado una nueva ciclina, llamada ciclina o, que es capaz de unirse y activar cdk2 en respuesta a est\u00edmulos apopt\u00f3ticos intr\u00ednsecos. Nos hemos centrado en el estudio de la ciclina oalfa y la ciclina obeta, productos de splicing alternativo del gen. En respuesta a diferentes tipos de estr\u00e9s, la ciclina oalfa se acumula en agregaciones citopl\u00e1smicas densas que podr\u00edan corresponder a gr\u00e1nulos de estr\u00e9s (sgs). Adem\u00e1s, hemos visto que la ciclina obeta y un mutante puntual de la parte n-terminal de la prote\u00edna se localizan constitutivamente en los sgs. Aunque las dos isoformas alfa y beta son proapopt\u00f3ticas, solo la ciclina oalfa es capaz de unirse y activar cdk2. Por otro lado, hemos demostrado que los niveles de ciclina o se incrementan en respuesta al estr\u00e9s de ret\u00edculo endopl\u00e1smico (re) y que esta prote\u00edna es necesaria para la inducci\u00f3n de apoptosis dependiente de estr\u00e9s de re.  La ciclina o activa espec\u00edficamente la v\u00eda de perk e interacciona con la prote\u00edna inhibidora de perk p58ipk. Adem\u00e1s, la ciclina o participa en la activaci\u00f3n de otras quinasas de eif2alfa. La ciclina o se localiza en mitocondrias activas, lo que sugiere una funci\u00f3n de la prote\u00edna ligada al metabolismo oxidativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Signalling of cyclin o complexes through eif2alpha phosphorylation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Signalling of cyclin o complexes through eif2alpha phosphorylation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Ortet Cortada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gabriel Gil G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia de herreros madue\u00f1o <\/li>\n<li>cristina Mu\u00f1oz pinedo (vocal)<\/li>\n<li>Elena Hidalgo hernando (vocal)<\/li>\n<li>susana De la luna gargantilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Ortet Cortada Hemos identificado una nueva ciclina, llamada ciclina o, que es capaz de unirse y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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