{"id":101534,"date":"2010-11-06T00:00:00","date_gmt":"2010-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-integrado-del-genoma-transcriptoma-y-proteinoma-del-huesped-en-la-infeccion-por-el-virus-de-la-hepatitis-c\/"},"modified":"2010-11-06T00:00:00","modified_gmt":"2010-11-06T00:00:00","slug":"estudio-integrado-del-genoma-transcriptoma-y-proteinoma-del-huesped-en-la-infeccion-por-el-virus-de-la-hepatitis-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enfermedades-infecciosas\/estudio-integrado-del-genoma-transcriptoma-y-proteinoma-del-huesped-en-la-infeccion-por-el-virus-de-la-hepatitis-c\/","title":{"rendered":"Estudio integrado del genoma, transcriptoma y proteinoma del hu\u00e9sped en la infecci\u00f3n por el virus de la hepatitis c"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aaangeles Jimenez Sousa <\/strong><\/h2>\n<p>La infecci\u00f3n por el virus de la hepatitis c es un problema sanitario a escala mundial con m\u00e1s de 170 millones de personas infectadas en el mundo. La historia natural de la infecci\u00f3n se caracteriza por una gran tendencia a la cronicidad, haciendo que esta enfermedad sea una causa significante de morbilidad y mortalidad. Su gravedad var\u00eda ampliamente pudiendo oscilar desde una infecci\u00f3n cr\u00f3nica asintom\u00e1tica hasta cirrosis y carcinoma hepatocelular. La infecci\u00f3n cr\u00f3nica por el virus de la hepatitis c induce la secreci\u00f3n mantenida de un amplio rango de mediadores solubles de la respuesta inmune relacionados con el desarrollo de inmunidad innata, inmunidad adquirida y fibrosis. El tratamiento combinado con peginterfer\u00f3n \u00c2\u00bf  y ribavirina induce, tanto en respondedores como en no respondedores, la activaci\u00f3n de genes de respuesta al interfer\u00f3n (isgs) tras doce semanas de tratamiento. Sin embargo, en el grupo de pacientes respondedores precoces, se observa la activaci\u00f3n de un mayor n\u00famero de isgs que en los que no responden de forma precoz. Independientemente del comportamiento de la carga viral y del comportamiento de los perfiles de expresi\u00f3n de isgs, el tratamiento induce la normalizaci\u00f3n de mediadores relacionados con respuestas adaptativas th1 y th17, as\u00ed como de factores profibr\u00f3ticos. Debido a este efecto inmunomodulador del tratamiento, la continuaci\u00f3n de la terapia podr\u00eda ser interesante no s\u00f3lo en aquellos pacientes respondedores sino tambi\u00e9n en los que no responden precozmente al tratamiento con el fin de disminuir el da\u00f1o tisular en el h\u00edgado. Por otra parte, la existencia de polimorfismos de un solo nucle\u00f3tido (rs3213545, rs1169279 y rs2859398) en el gen oasl de la ruta del ifn predice la respuesta al tratamiento combinado. La detecci\u00f3n de estos snps nos podr\u00eda ayudar por tanto a predecir cu\u00e1les son los pacientes que presentan una mayor probabilidad de responder al tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio integrado del genoma, transcriptoma y proteinoma del hu\u00e9sped en la infecci\u00f3n por el virus de la hepatitis c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio integrado del genoma, transcriptoma y proteinoma del hu\u00e9sped en la infecci\u00f3n por el virus de la hepatitis c <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aaangeles Jimenez Sousa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Francisco Bermejo Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raul Ortiz de lejarazu leonardo <\/li>\n<li>salvador Resino garcia (vocal)<\/li>\n<li>m. Elena Seoane reula (vocal)<\/li>\n<li>milagros Gonzalez rivera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aaangeles Jimenez Sousa La infecci\u00f3n por el virus de la hepatitis c es un problema sanitario a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1085,12451],"tags":[188016,76215,122838,206323,4947,131654],"class_list":["post-101534","post","type-post","status-publish","format-standard","hentry","category-enfermedades-infecciosas","category-valladolid","tag-jesus-francisco-bermejo-martin","tag-m-elena-seoane-reula","tag-milagros-gonzalez-rivera","tag-maangeles-jimenez-sousa","tag-raul-ortiz-de-lejarazu-leonardo","tag-salvador-resino-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=101534"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101534\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=101534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=101534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=101534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}