{"id":10166,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/regulacion-metabolica-y-tejido-especifica-de-la-expresion-del-gen-de-la-hmg-coa-sintasa-mitocondrial\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"regulacion-metabolica-y-tejido-especifica-de-la-expresion-del-gen-de-la-hmg-coa-sintasa-mitocondrial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-metabolica-y-tejido-especifica-de-la-expresion-del-gen-de-la-hmg-coa-sintasa-mitocondrial\/","title":{"rendered":"Regulacion metabolica y tejido-especifica de la expresion del gen de la hmg-coa sintasa mitocondrial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Carles Rodr\u00edguez Rubio <\/strong><\/h2>\n<p>La activacion transcripcional del gen de la hmg-coa sintasa mitocondrial por acidos grasos se produce a traves del factor de transcripcion ppar. El promotor del gen de la hmg-coa sintasa mitocondrial posee un elemento de respuesta a ppar (denominado ppre) que consiste en una repeticion directa imperfecta del hexamero tgacct, separada por un nucleotido, y comprendida entre las posiciones-104 y -92. Este ppre es suficiente y necesario para conferir respuesta a ppar al promotor del gen, y es capaz de conferir sensibilidad a ppar a un promotor heterologo. Ppar se une al ppre mediante heterodimeros con rxr, el receptor del acido 9-cisretinoico. Ademas, la secuencia corriente abajo inmediata al ppre es necesaria para la union del heterodimero ppar-rxr. Por otra parte, la conversion adiposa de los fibroblastos 3t3-l1 induce la expresion del gen de la hmg-coa sintasa mitocondrial, probablemente por un mecanismo mediado por ppar. Otro factor de transcripcion, coup-tf, tiene un papel dual en el control de la transcripcion del gen de la hmg-coa sintasa mitocondrial y dependiente del contexto celular:  actua como activador en celulas de hepatoma hepg2 y como represor en celulas tumorales de leydig r2c. La activacion por coup-tf es promovida por la secuencia comprendida entre las posiciones -62 y +28. La represion por coup-tf se realiza a traves del ppre. Coup-tf inhibe la activacion por ppar tanto en el promotor del gen de la hmg-coa sintasa mitocondrial en celulas r2c, como en un promotor heterologo que contenga el ppre en celulas hepg2. Otro factor de transcripcion, hnf-4, inhibe la activacion mediada por ppar del gen de la hmg-coa sintasa mitocondrial. Considerando esta concurrencia de fenomenos identificados aisladamente y de forma excepcional en otros genes, el promotor de la hmg-coa sintasa mitocondrial constituye un modelo singular de regulacion transcripcional.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion metabolica y tejido-especifica de la expresion del gen de la hmg-coa sintasa mitocondrial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion metabolica y tejido-especifica de la expresion del gen de la hmg-coa sintasa mitocondrial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Carles Rodr\u00edguez Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Haro Bautista<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fausto Garcia Hegardt <\/li>\n<li>Alberto Mu\u00f1oz Terol (vocal)<\/li>\n<li>Manuel Palac\u00edn Prieto (vocal)<\/li>\n<li>Anna Messeguer Navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Carles Rodr\u00edguez Rubio La activacion transcripcional del gen de la hmg-coa sintasa mitocondrial por acidos grasos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,160,115,17],"tags":[15488,34233,34232,400,34231,7153],"class_list":["post-10166","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alberto-munoz-terol","tag-anna-messeguer-navarro","tag-diego-haro-bautista","tag-fausto-garcia-hegardt","tag-joan-carles-rodriguez-rubio","tag-manuel-palacin-prieto"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/10166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=10166"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/10166\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=10166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=10166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=10166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}