{"id":101707,"date":"2018-03-11T10:23:38","date_gmt":"2018-03-11T10:23:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/phenotypical-and-transcriptional-biomarkers-in-organ-transplantation\/"},"modified":"2018-03-11T10:23:38","modified_gmt":"2018-03-11T10:23:38","slug":"phenotypical-and-transcriptional-biomarkers-in-organ-transplantation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/phenotypical-and-transcriptional-biomarkers-in-organ-transplantation\/","title":{"rendered":"Phenotypical and transcriptional biomarkers in organ transplantation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Puig-pey Comas <\/strong><\/h2>\n<p>1r estudio. Caracterizaci\u00f3n fenot\u00edpica y funcional de las supoblaciones vdelta1 y vdelta2 en trasplantados de h\u00edgado (tolerantes y receptores en tratamiento inmunosupresor), receptores de un trasplante de ri\u00f1\u00f3n, pacientes en lista de espera de trasplante de h\u00edgado y controles sanos. El objetivo es quantificar las subpoblaciones gammadelta en estos grupos de pacientes y profundizar en su rol efector y\/o tolerog\u00e9nico.  Se observa una expansi\u00f3n en trasplantados de la poblaci\u00f3n gammadelta, debido a un incremento de la subpoblaci\u00f3n vd1 y una disminuci\u00f3n de vd2 que es significativo en tolerantes e induce una inversi\u00f3n del ratio vd1\/vd2. Ambas subpoblaciones tienen un perfil fenot\u00edpico totalmente distinto. Vd1 se aemeja a la poblaci\u00f3 alphabeta t efectora de memoria diferenciada (temra). tambi\u00e9n se valora la influencia de infeccuiones v\u00edricas persistentes (vhc y cmv) en la expresi\u00f3n de las nombradas subpoblaciones, se observa que los pacientes seropositivos muestran un aumento en la poblaci\u00f3n vdelta1. Determinamos la estabilidad del fenotipo vdelta1 y vdelta 2 en un perodo de tiempo establecido. Se estudia tambi\u00e9n su capacidad diagn\u00f3stica como marcadores de tolerancia operacional, para diferenciar pacientes tolerantes y trasplantados de h\u00edgado en tratamiento inmunosupresor. Las subpoblaciones gammadelta no muestran ser una buena herramienta diagn\u00f3stica (especificidad y sensibilidad bajas).  2\u00c2\u00ba estudio. Determinar el perfil de expresi\u00f3n g\u00e9nica y fen\u00f3tipica que inducen sirolimus y ciclosporina a en pacientes estables trasplantados de ri\u00f1\u00f3n en monoterapia. Se determinan las principales vias metab\u00f3licas y de se\u00f1alizaci\u00f3n, as\u00ed como las poblaciones celulares expresadas significativamente en las dos cohortes de pacientes. Se valora el posible perfil tolerog\u00e9nico en ambas cohortes a partir de una \u00absiganture\u00bb de tolerancia definida anteriormente en pacientes tolerantes trasplantados de ri\u00f1\u00f3n. describimos una tendencia en sirolimus a expresar c\u00e9lulas t reguladoras, y encontarmos diferenncias tambi\u00e9n en los fenot\u00edpos de memoria\/na\u00ed\u00afve\/efector. en pacientes con sirolimus seleccionamos un 1000 genes sobre\/infraexpresados por microarrays y detectamos un enriquecimiento en vias metab\u00f3licas pro-inflamatorias y relacionas con se\u00f1alizaci\u00f3n mtor. No se detecto perfil tolerog\u00e9nico en ninguna de las dos cohortes estudiadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Phenotypical and transcriptional biomarkers in organ transplantation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Phenotypical and transcriptional biomarkers in organ transplantation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Puig-pey Comas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Sanchez Fueyo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: azucena Salas mart\u00ednez <\/li>\n<li>oriol Bestard matamoros (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Puig-pey Comas 1r estudio. Caracterizaci\u00f3n fenot\u00edpica y funcional de las supoblaciones vdelta1 y vdelta2 en trasplantados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,1737,2953],"tags":[36952,206606,206605,196482],"class_list":["post-101707","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-inmunologia","category-trasplante-de-organos","tag-alberto-sanchez-fueyo","tag-azucena-salas-Martinez","tag-isabel-puig-pey-comas","tag-oriol-bestard-matamoros"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=101707"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101707\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=101707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=101707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=101707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}