{"id":101788,"date":"2018-03-11T10:23:42","date_gmt":"2018-03-11T10:23:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-cromatina-en-el-lugar-de-integracion-sobre-la-actividad-del-promotor-del-virus-de-la-inmunodeficiencia-humana-y-el-establecimiento-de-la-latencia-viral\/"},"modified":"2018-03-11T10:23:42","modified_gmt":"2018-03-11T10:23:42","slug":"influencia-de-la-cromatina-en-el-lugar-de-integracion-sobre-la-actividad-del-promotor-del-virus-de-la-inmunodeficiencia-humana-y-el-establecimiento-de-la-latencia-viral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/acidos-nucleicos\/influencia-de-la-cromatina-en-el-lugar-de-integracion-sobre-la-actividad-del-promotor-del-virus-de-la-inmunodeficiencia-humana-y-el-establecimiento-de-la-latencia-viral\/","title":{"rendered":"Influencia de la cromatina en el lugar de integraci\u00f3n sobre la actividad del promotor del virus de la inmunodeficiencia humana y el establecimiento de la latencia viral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Edurne Gallastegui Calvache <\/strong><\/h2>\n<p>El establecimiento de un reservorio latente del virus del hiv en c\u00e9lulas t cd4+ es la mayor barrera contra la erradicaci\u00f3n de esta enfermedad, convirti\u00e9ndola en cr\u00f3nica. Para lograr su erradicaci\u00f3n, se necesitar\u00eda combinar la terapia antirretroviral haart con drogas capaces de reactivar los virus durmientes. El objetivo principal de este estudio es entender c\u00f3mo se establece la latencia tras la integraci\u00f3n del virus en el genoma, con el prop\u00f3sito de identificar factores involucrados que pudieran ser las dianas de una nueva terapia. Hemos generado una librer\u00eda de clones que contienen un minigenoma latente del virus que expresa gfp como reportero cuando se reactiva. Esta librer\u00eda permite estudiar la posible relaci\u00f3n existente entre el estado de la cromatina en el lugar de integraci\u00f3n y la actividad del promotor. Tambi\u00e9n hemos estudiado la implicaci\u00f3n de la interferencia transcripcional en el establecimiento de la latencia en los clones cuya integraci\u00f3n del hiv ha tenido lugar en genes transcripcionalmente activos. Para investigar el mecanismo de represi\u00f3n durante la latencia, se han llevado a cabo depleciones de factores relacionados con el reensamblaje de la cromatina y prote\u00ednas relacionadas con represi\u00f3n transcripcional mediante expresi\u00f3n de shrnas. Finalmente, hemos buscado drogas que puedan reactivar el virus latente como posible terapia a combinar con la terapia antiretroviral con el objetivo de erradicar completamente el virus en pacientes cr\u00f3nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la cromatina en el lugar de integraci\u00f3n sobre la actividad del promotor del virus de la inmunodeficiencia humana y el establecimiento de la latencia viral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la cromatina en el lugar de integraci\u00f3n sobre la actividad del promotor del virus de la inmunodeficiencia humana y el establecimiento de la latencia viral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Edurne Gallastegui Calvache <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Jordan Valles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carles Mar\u00eda Su\u00f1e negre <\/li>\n<li>sara Pagans lista (vocal)<\/li>\n<li>Javier Martinez picado (vocal)<\/li>\n<li>eduardo Mu\u00f1oz blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Edurne Gallastegui Calvache El establecimiento de un reservorio latente del virus del hiv en c\u00e9lulas t cd4+ [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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