{"id":101795,"date":"2018-03-11T10:23:42","date_gmt":"2018-03-11T10:23:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-conexina-43-como-modulador-de-la-captacion-de-glucosa-en-astrocitos\/"},"modified":"2018-03-11T10:23:42","modified_gmt":"2018-03-11T10:23:42","slug":"la-conexina-43-como-modulador-de-la-captacion-de-glucosa-en-astrocitos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/historia-de-la-farmacia\/la-conexina-43-como-modulador-de-la-captacion-de-glucosa-en-astrocitos\/","title":{"rendered":"La conexina 43 como modulador de la captaci\u00f3n de glucosa en astrocitos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Carlos Valle Casuso <\/strong><\/h2>\n<p>Los astrocitos juegan un papel importante en el metabolismo del cerebro. Los astrocitos est\u00e1n comunicados a trav\u00e9s de las \u00abgap junctions\u00bb, compuestas en su mayor\u00eda por una prote\u00edna denominada conexina43 (cx43). Entre una de las funciones de estas uniones en su mayor\u00eda se encuentra en paso de glucosa y otros metabolitos. En nuestros trabajos previos, hemos mostrado que la endotelina-1 (et-1), un inhibidor de las \u00abgap junctions\u00bb, promueve un aumento en la velocidad de captaci\u00f3n de glucosa.  en este trabajo nosotros estudiaremos la explicaci\u00f3n a un posible mecanismo. para ello primero silenciamos la cx43 con un sirna espec\u00edfico en astrocitos en cultivo primario, para posteriormente tratar a estos con et-1. Nuestros resultados mostraron que la inhibici\u00f3n de la formaci\u00f3n de las \u00abgap junctions\u00bb por sirna aumenta la captaci\u00f3n de glucosa y la expresi\u00f3n de las proteinas implicadas en el proceso, as\u00ed como que la et-1 necesita de la cx43 para ejercer su acci\u00f3n como promotor del aumento de la velocidad de la captaci\u00f3n de glucosa en astrocitos. Posteriormente y esta vez sobre un modelo \u00abin vivo\u00bb de perdida de cx43 por inyecci\u00f3n de \u00e1cido ka\u00ednico en la corteza cerebral de rat\u00f3n adulto, nuestro resultados de inmunohistoqu\u00edmica mostraron un aumento de los niveles de et-1 en la zona lesionada y de la expresi\u00f3n de las prote\u00ednas encargadas de la captaci\u00f3n de glucosa en astrocitos. En conclusi\u00f3n nuestros resultados indican que la proteina cx43 componente de las \u00abgap junctions\u00bb regula la captaci\u00f3n de glucosa en astrocitos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La conexina 43 como modulador de la captaci\u00f3n de glucosa en astrocitos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La conexina 43 como modulador de la captaci\u00f3n de glucosa en astrocitos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Carlos Valle Casuso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Medina Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>christian Giaume (vocal)<\/li>\n<li>anna Gum\u00ed\u00a0 garcia (vocal)<\/li>\n<li>rosario Arevalo arevalo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Carlos Valle Casuso Los astrocitos juegan un papel importante en el metabolismo del cerebro. Los astrocitos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[360,9386],"tags":[190386,86070,3180,206757,7301,25755],"class_list":["post-101795","post","type-post","status-publish","format-standard","hentry","category-historia-de-la-farmacia","category-salamanca","tag-anna-gumi-garcia","tag-christian-giaume","tag-enrique-blazquez-fernandez","tag-jose-carlos-valle-casuso","tag-jose-maria-medina-jimenez","tag-rosario-arevalo-arevalo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=101795"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101795\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=101795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=101795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=101795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}