{"id":101838,"date":"2018-03-11T10:23:47","date_gmt":"2018-03-11T10:23:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/individual-based-modeling-of-plasmodium-falciparum-erythrocyte-infection-in-in-vitro-cultures\/"},"modified":"2018-03-11T10:23:47","modified_gmt":"2018-03-11T10:23:47","slug":"individual-based-modeling-of-plasmodium-falciparum-erythrocyte-infection-in-in-vitro-cultures","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/individual-based-modeling-of-plasmodium-falciparum-erythrocyte-infection-in-in-vitro-cultures\/","title":{"rendered":"Individual-based modeling of plasmodium falciparum erythrocyte infection in in vitro cultures"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jordi Ferrer Savall <\/strong><\/h2>\n<p>Malaria is still a major burden that causes approximately one million deaths annually worldwide. Its  eradication supposes  a great challenge to the humanity and to the scientific community, in particular. In  vitro cultivation of the parasite is essential for the development of new drugs. Current culture methods are  based on heuristics and demand for specific improvements.    the present thesis is a theoretical approach to in vitro cultivation of the protozoan parasite plasmodium  falciparum infecting human red blood cells. It mainly focuses on the process of building a model of  appropriate complexity to deal with the specific demands above mentioned, but it also includes the  formulation and implementation of algorithms, and the design and execution of experimental trials.   this kind of work requires multidisciplinary collaboration: the insight of the experts in malaria research is  complemented with modeling and simulation, which allows for checking settled assumptions, increasing  the understanding on the system and improving the current culturing methods.  the use of tools for building, analyzing and sharing models is an imperative to this end. In this thesis,  pattern-oriented modeling (pom) has been adopted as the most appropriate way for raising of models and  the odd protocol (objectives, design concepts and details) has been proposed as the standard tool for  communicating them.     individual-based modeling (ibm) has been used to tackle malaria culture systems. Ibms define a set of  rules governing each cell, its interactions with others and with its immediate surroundings. From this set of  rules, and taking into account diversity within the population and a certain degree of randomness in the  individual processes, ibms explicitly show the emerging behavior of the system as a whole. Methods from  statistical thermodynamics have been applied to understand the emergence of macroscopic patterns from  the population structure (e.G. Distribution of infection stages among infected red blood cells).    the research resulted in the development of the model and simulator indisim-rbc, which has proved  to be a good tool to improve understanding of the cultures under study. It is a mechanistically rich  individual-based model and it quantitatively reproduces and predicts several patterns observed in real  cultures at different levels of description.      we demonstrated that indisim-rbc can be used to study in detail several aspects of malaria  cultivation that remained unclear, as well as to perform virtual experiments.  Consequently, it can be used  to  open novel lines of research and to examine potential experimental techniques. Indisim-rbc has also  been used to improve the current experimental culturing protocols in static cultivation by obtaining the  optimal geometry of the hematocrit layer and subcultivation periods in the continuous cultures.    this study on malaria has been compared to the research carried out by the group regarding other  microbial communities. Thereby studying general emerging properties of microbial systems in general,  with regard to the effect of cell individuality, heterogeneity and diversity, the local nature of interactions;  and biological and spatial complexity. In doing so, the acquired holistic view has been used to develop  tools that allow for a better characterization and study of the infection process, in particular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Individual-based modeling of plasmodium falciparum erythrocyte infection in in vitro cultures<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Individual-based modeling of plasmodium falciparum erythrocyte infection in in vitro cultures <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jordi Ferrer Savall <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Polit\u00e9cnica de catalunya<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel L\u00f3pez Codina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Vives rego <\/li>\n<li>domingo Gargallo viola (vocal)<\/li>\n<li>simone Ladeia andrade (vocal)<\/li>\n<li>moises Silbert (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jordi Ferrer Savall Malaria is still a major burden that causes approximately one million deaths annually worldwide. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8036,278,516,15596,13227],"tags":[143897,102115,206840,1260,79821,206841],"class_list":["post-101838","post","type-post","status-publish","format-standard","hentry","category-biofisica","category-microbiologia","category-parasitologia-humana","category-politecnica-de-catalunya","category-simulacion","tag-daniel-lopez-codina","tag-domingo-gargallo-viola","tag-jordi-ferrer-savall","tag-josep-vives-rego","tag-moises-silbert","tag-simone-ladeia-andrade"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=101838"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101838\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=101838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=101838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=101838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}