{"id":101907,"date":"2018-03-11T10:23:52","date_gmt":"2018-03-11T10:23:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/preclinical-study-of-pi3k-and-braf-inhibitions-in-malignant-melanoma-estudio-precla%c2%adnico-de-inhibidores-de-pi3k-y-braf-en-melanoma-maligno\/"},"modified":"2018-03-11T10:23:52","modified_gmt":"2018-03-11T10:23:52","slug":"preclinical-study-of-pi3k-and-braf-inhibitions-in-malignant-melanoma-estudio-precla%c2%adnico-de-inhibidores-de-pi3k-y-braf-en-melanoma-maligno","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/preclinical-study-of-pi3k-and-braf-inhibitions-in-malignant-melanoma-estudio-precla%c2%adnico-de-inhibidores-de-pi3k-y-braf-en-melanoma-maligno\/","title":{"rendered":"Preclinical study of pi3k and braf inhibitions in malignant melanoma (estudio precl\u00ednico de inhibidores de pi3k y braf en melanoma maligno)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta L\u00f3pez Fauqued <\/strong><\/h2>\n<p>El melanoma maligno es el tipo de c\u00e1ncer de piel m\u00e1s agresivo que existe. Los melanomas detectados en estad\u00edos tempranos de desarrollo de la enfermedad pueden ser tratados por cirug\u00eda. Sin embargo, los melanomas m\u00e1s avanzados son resistentes a las terapias act\u00faales y no existe ning\u00fan tratamiento efectivo.  numerosos estudios en muestras humanas de melanoma indican que las v\u00edas de se\u00f1alizaci\u00f3n de ras\/raf\/erk2 y pi3k son importantes en el desarrollo y progresi\u00f3n del melanoma. Por ello, son dos buenas candidatas a inhibir mediante compuestos espec\u00edficos en la terapia del melanoma. En este trabajo, se describe un estudio precl\u00ednico en melanoma cut\u00e1neo maligno utilizando sorafenib (bayer), un inhibidor de kinasas raf y  pi-103 (piramed-genentec), un inhibidor dual de pi3k\/mtor. Los resultados mostraron que ambas drogas inhib\u00edan de forma dosis-dependiente la proliferaci\u00f3n celular in vitro. Adem\u00e1s, la combinaci\u00f3n de ambas drogas inhib\u00eda sinerg\u00edsticamente la proliferaci\u00f3n celular in vitro. Sin embargo, no se observ\u00f3 este efecto bloqueando el crecimiento tumoral en ratones inmunocompetentes. Sorprendentemente, el tratamiento in vivo con pi-103 en estos ratones inmunocompetentes induc\u00eda inmunosupresi\u00f3n, crecimiento tumoral y bloqueaba la apoptosis. Adem\u00e1s, estudios realizados en l\u00edneas celulares derivadas de tumores indicaron que pi-103 induc\u00eda la expresi\u00f3n de las prote\u00ednas antiapoptoticas de la fam\u00edlia bh3 mcl1, bcl2 y bclxl  favoreciendo as\u00ed el efecto observado.  estos datos argumentan el uso de modelos animales m\u00e1s fisiol\u00f3gicos en estudios precl\u00ednicos para poder detectar posibles efectos sist\u00e9micos no deseados producidos por las drogas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Preclinical study of pi3k and braf inhibitions in malignant melanoma (estudio precl\u00ednico de inhibidores de pi3k y braf en melanoma maligno)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Preclinical study of pi3k and braf inhibitions in malignant melanoma (estudio precl\u00ednico de inhibidores de pi3k y braf en melanoma maligno) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta L\u00f3pez Fauqued <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Angel Recio Conde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier L\u00f3pez soriano <\/li>\n<li>joan-marc Servitja duque (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta L\u00f3pez Fauqued El melanoma maligno es el tipo de c\u00e1ncer de piel m\u00e1s agresivo que existe. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951],"tags":[33986,147921,206948,206947],"class_list":["post-101907","post","type-post","status-publish","format-standard","hentry","category-barcelona","tag-francisco-javier-lopez-soriano","tag-joan-marc-servitja-duque","tag-juan-angel-recio-conde","tag-marta-lopez-fauqued"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=101907"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/101907\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=101907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=101907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=101907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}