{"id":102016,"date":"2018-03-11T10:24:01","date_gmt":"2018-03-11T10:24:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-mecanismos-moleculares-implicados-en-la-carcinogenesis-producida-por-b-raf\/"},"modified":"2018-03-11T10:24:01","modified_gmt":"2018-03-11T10:24:01","slug":"nuevos-mecanismos-moleculares-implicados-en-la-carcinogenesis-producida-por-b-raf","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/proteinas\/nuevos-mecanismos-moleculares-implicados-en-la-carcinogenesis-producida-por-b-raf\/","title":{"rendered":"Nuevos mecanismos moleculares implicados en la carcinog\u00e9nesis producida por b-raf"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene S\u00e1nchez Hern\u00e1ndez <\/strong><\/h2>\n<p>La prote\u00edna b-raf forma parte de la v\u00eda de se\u00f1alizaci\u00f3n de ras-raf-mek-erk y regula, entre otros, la proliferaci\u00f3n y la supervivencia celulares, dos procesos clave para la transformaci\u00f3n celular. Se han encontrando mutaciones activadoras de b-raf en un 10-20% de tumores humanos y, en concreto, v600eb-raf se considera un oncog\u00e9n. Por ello, es importante y necesario un mejor entendimiento de la regulaci\u00f3n de los procesos biol\u00f3gicos modulados por v600eb-raf en c\u00e1ncer.  en este trabajo nosotros demostramos que v600eb-raf es el principal activador de la v\u00eda mek-erk y el responsable de la proliferaci\u00f3n de las c\u00e9lulas tumorales que lo contienen.  por otro lado nuestros resultados demuestran que v600eb-raf protege de la apoptosis por regulaci\u00f3n de prote\u00ednas de la maquinaria apopt\u00f3tica celular como bim y caspasa 3. Sorprendentemente, su papel en apoptosis es independiente de la activaci\u00f3n de mek-erk. Adem\u00e1s, nosotros observamos que la v\u00eda pi3k-akt-mtor coopera con b-raf en la supervivencia de las c\u00e9lulas tumorales estudiadas.  por \u00faltimo, nosotros demostramos que v600eb-raf regula la transcripci\u00f3n dependiente de nfb por dos mecanismos distintos, uno a trav\u00e9s de la v\u00eda can\u00f3nica y otro aumentando la transactivaci\u00f3n de p65\/rela a trav\u00e9s de la quinasa msk1. Adem\u00e1s, la activaci\u00f3n de nfb por v600eb-raf es dependiente de mek-erk y, por lo tanto, no est\u00e1 implicada en la supervivencia celular inducida por este oncog\u00e9n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos mecanismos moleculares implicados en la carcinog\u00e9nesis producida por b-raf<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos mecanismos moleculares implicados en la carcinog\u00e9nesis producida por b-raf <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene S\u00e1nchez Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Chiloeches Galvez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: M\u00aa josefa Toro nozal <\/li>\n<li>Andr\u00e9s Castellanos mart\u00edn (vocal)<\/li>\n<li>marina Lasa benito (vocal)<\/li>\n<li>marina i. Gar\u00edn ferreira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene S\u00e1nchez Hern\u00e1ndez La prote\u00edna b-raf forma parte de la v\u00eda de se\u00f1alizaci\u00f3n de ras-raf-mek-erk y regula, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,8901,3178],"tags":[207110,119014,207109,207111,31784,14322],"class_list":["post-102016","post","type-post","status-publish","format-standard","hentry","category-alcala","category-carcinogenesis","category-proteinas","tag-andres-castellanos-martin","tag-antonio-chiloeches-galvez","tag-irene-sanchez-hernandez","tag-marina-i-garin-ferreira","tag-marina-lasa-benito","tag-ma-josefa-toro-nozal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102016"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102016\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}