{"id":102032,"date":"2018-03-11T10:24:01","date_gmt":"2018-03-11T10:24:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-los-polimorfismos-cyp2c92-y-cyp1c93-en-la-sensibilidad-al-acenocumarol\/"},"modified":"2018-03-11T10:24:01","modified_gmt":"2018-03-11T10:24:01","slug":"influencia-de-los-polimorfismos-cyp2c92-y-cyp1c93-en-la-sensibilidad-al-acenocumarol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-los-polimorfismos-cyp2c92-y-cyp1c93-en-la-sensibilidad-al-acenocumarol\/","title":{"rendered":"Influencia de los polimorfismos cyp2c9*2 y cyp1c9*3 en la sensibilidad al acenocumarol."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Valle Borrego <\/strong><\/h2>\n<p>El acenocumarol (sintrom\u00c2\u00ae) es el anticoagulante oral m\u00e1s utilizado en espa\u00f1a y en el resto de pa\u00edses europeos. Su mecanismo de acci\u00f3n consiste en la inhibici\u00f3n de la vitamina k, co-factor  esencial para la s\u00edntesis hep\u00e1tica de los principales factore s de la coagulaci\u00f3n. Se metaboliza principalmente por el citocromo p450 2c9 (cyp2c9), el cual es tambi\u00e9n responsable del metabolismo de otros f\u00e1rmacos, como sulfonilureas, estatinas, amiodarona , inhibidores de la enzima convertidora de angiotensina,  antagonistas de los receptores de angiotensina ii, propafenona, etc. existen varias mutaciones en el gen que codifica la enzima microsomal hep\u00e1tica del cyp2c9; los m\u00e1s frecuentes y mejor documentados alelos, designados como  cyp2c9*2 y cyp2c9*3, se asocian con una capacidad alterada para metabolizar el acenocumarol, resultando en una mayor vida media de \u00e9ste. Estas mutaciones son responsables independientes de los menores requerimientos de acenocumarol que se observan en individuos con combinac iones de estos polimorfismos.  en el estudio realizado hemos objetivado que los pacientes portadores de una o m\u00e1s combinaciones de los alelos  cyp2c9*2 y cyp2c9*3 precisan para su control dosis de acenocumarol significativamente m\u00e1s bajas que aquello s con genotipo salvaje (cyp2c9*1\/*1), sin que esto suponga un aumento en la aparici\u00f3n de fen\u00f3menos hemorr\u00e1gicos en estos pacientes. asimismo, hemos encontrado que la edad es un factor independiente que influye en la dosis de acenocumarol precisada: l os pacientes de edad avanzada precisan unas dosis de acenocumarol inferiores a las de los pacientes m\u00e1s j\u00f3venes. planteamos la realizaci\u00f3n de un test de genotipado previo al tratamiento anticoagulante oral para conocer qu\u00e9 pacientes son portadores de  los polimorfismos cyp2c9*2 y cyp2c9*3, y, en estos casos, comenzar el tratamiento con dosis de acenocumarol m\u00e1s bajas de las utilizadas de forma habitual, consiguiendo as\u00ed acortar el tiempo hasta la estabilizaci\u00f3n de la dosis de anticoagulante oral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de los polimorfismos cyp2c9*2 y cyp1c9*3 en la sensibilidad al acenocumarol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de los polimorfismos cyp2c9*2 y cyp1c9*3 en la sensibilidad al acenocumarol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Valle Borrego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elpidio Miguel Calvo Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>Manuel Rodriguez zapata (vocal)<\/li>\n<li>Francisco Arnalich fern\u00e1ndez (vocal)<\/li>\n<li>gonzalo Garcia de casasola sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Valle Borrego El acenocumarol (sintrom\u00c2\u00ae) es el anticoagulante oral m\u00e1s utilizado en espa\u00f1a y en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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