{"id":102048,"date":"2018-03-11T10:24:06","date_gmt":"2018-03-11T10:24:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-analogos-de-la-vitamina-d-con-cadena-lateral-furanica-y-alenica\/"},"modified":"2018-03-11T10:24:06","modified_gmt":"2018-03-11T10:24:06","slug":"sa%c2%adntesis-de-analogos-de-la-vitamina-d-con-cadena-lateral-furanica-y-alenica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/sa%c2%adntesis-de-analogos-de-la-vitamina-d-con-cadena-lateral-furanica-y-alenica\/","title":{"rendered":"S\u00edntesis de an\u00e1logos de la vitamina d con cadena lateral fur\u00e1nica y al\u00e9nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ram\u00f3n Fraga Mallo <\/strong><\/h2>\n<p>El metabolito hormonal activo de la vitamina d3, 1alpha,25-dihidroxivitamina d3, posee un amplio espectro de importantes actividades biol\u00f3gicas que inciden en varias \u00e1reas terap\u00e9uticas (dermatolog\u00eda, enfermedades metab\u00f3licas, osteoporosis, oncolog\u00eda y enfermedades del sistema inmune). La aprobaci\u00f3n reciente de su uso para el tratamiento de la psoriasis en varios pa\u00edses despert\u00f3 un renovado inter\u00e9s, sobre todo en varias industrias farmac\u00e9uticas (solvay pharmaceuticals bv, dishman netherlands bv, hoffman lana roche, dsm nutritional products) por el desarrollo de una s\u00edntesis eficiente de estos compuestos. Se proponen una s\u00edntesis optimizada donde la etapa clave es la formaci\u00f3n del sistema tri\u00e9nico v\u00eda reacciones catalizadas por pd(0) (ciclaci\u00f3n de negishi o suzuki) a partir de un organomet\u00e1lico de zn o un \u00e9ster bor\u00f3nico (biciclo cd-cadena lateral) y un triflato vin\u00edlico (sortija la). Se proponen rutas cortas y novedosas de s\u00edntesis de an\u00e1logos con cadena lateral semirr\u00edgida, fur\u00e1nica y al\u00e9nica que conllevan el empleo de catalizadores de oro y otros organomet\u00e1licos. La s\u00edntesis propuesta conlleva muchos menos pasos que las existentes, no utiliza vitamina d2 c\u00f3mo material de partida y evita procedimientos m\u00e1s complicados para la formaci\u00f3n del sistema tri\u00e9nico como la preparaci\u00f3n del \u00f3xido de fosfina (ruta lythgoe) o la hidrogenaci\u00f3n parcial de dieninos (ruta lythgoe-santiago). La estrategia es de potencial inter\u00e9s para la s\u00edntesis de metabolitos de la vitamina d3 y d2 as\u00ed como an\u00e1logos de potencial inter\u00e9s terap\u00e9utico, tanto a nivel b\u00e1sico como industrial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de an\u00e1logos de la vitamina d con cadena lateral fur\u00e1nica y al\u00e9nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de an\u00e1logos de la vitamina d con cadena lateral fur\u00e1nica y al\u00e9nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ram\u00f3n Fraga Mallo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mouri\u00f1o Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Vilarrasa llorens <\/li>\n<li>Francisco Bermejo gonzalez (vocal)<\/li>\n<li>hans-g\u00ed\u00bcnther Schamalz (vocal)<\/li>\n<li>martin john Calverley (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ram\u00f3n Fraga Mallo El metabolito hormonal activo de la vitamina d3, 1alpha,25-dihidroxivitamina d3, posee un amplio espectro [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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