{"id":102049,"date":"2018-03-11T10:24:06","date_gmt":"2018-03-11T10:24:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-ovario-factores-pronosticos\/"},"modified":"2018-03-11T10:24:06","modified_gmt":"2018-03-11T10:24:06","slug":"cancer-de-ovario-factores-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/cancer-de-ovario-factores-pronosticos\/","title":{"rendered":"\u00abcancer de ovario. factores pronosticos\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Delia Garcia Marrero <\/strong><\/h2>\n<p>Introducci\u00f3n. Existen gran cantidad de factores pron\u00f3sticos establecidos en el c\u00e1ncer epitelial de ovario (ceo), ya sean cl\u00ednicos, anatomo-patol\u00f3gicos y moleculares. Dentro de este subgrupo podr\u00edamos vamos a estudiar las prote\u00ednas del complejo molecular denominado nuclear factor kappa-b (nf-kb), descritas en diversas neoplasias s\u00f3lidas y relacionadas con factores de mal pron\u00f3sticos en algunos casos tales como en el c\u00e1ncer de pulm\u00f3n, de pr\u00f3stata y en determinados s\u00edndromes linfoproliferativos.  Objetivos. En el siguiente estudio analizamos la expresi\u00f3n de las distintas caracter\u00edsticas clinicas, anatomopatol\u00f3gicas y moleculares de nuestra poblacion analizada con c\u00e1ncer de ovario, e intamos demostrar si la expresi\u00f3n de las prote\u00ednas nf-kb (c-rel, p50, p52, p65 y rel-b) influyen como factor pron\u00f3stico independiente en el ceo. Material y m\u00e9todos. Analizamos, en 175 paciente diagnosticas y tratadas de ceo en un mimo centro, las carater\u00edsticas cl\u00ednicas y anatomopatol\u00f3gicas del tumor y, en 97 de estas pacientes, analizamos la expresi\u00f3n molecular de las distintas prote\u00ednas que conforman el complejo molecular nf-kb, mediante la creaci\u00f3n de tissue microarrays y t\u00e9cnicas de inmunohistoqu\u00edmica sobre los bloques de parafina de dichas pacientes. Resultados. Encontramos como un aumento de la expresi\u00f3n nuclear de la prote\u00edna nf-k b p52 estaba asociada, de forma estad\u00edsticamente significativa, con tumores en estadios avanzados (e iii-iv), con mal estado general al diagn\u00f3stico (ecog 2-3),  con la presencia de enfermedad residual tras la cirug\u00eda \u00f3ptima, con los tumores serosos y con los tumores m\u00e1s indiferenciados. As\u00ed mismo, el aumento de la expresi\u00f3n nuclear de nf-kb c- rel tambi\u00e9n se relacion\u00f3, de forma estad\u00edsticamente significativa, con el mayor grado de diferenciaci\u00f3n histol\u00f3gica. Sin embargo, no encontramos ninguna relaci\u00f3n de las prote\u00ednas nf-kb con la supervivencia global ni con la supervivencia libre de enfermedad. Conclusi\u00f3n. Los resultados del an\u00e1lisis multivariante no mostraron que la mayor expresi\u00f3n nuclear de las prote\u00ednas nf-kb pudiera considerarse como factor pron\u00f3stico independiente para el ceo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abcancer de ovario. factores pronosticos\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abcancer de ovario. factores pronosticos\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Delia Garcia Marrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Norberto Batista L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Santolaria fern\u00e1ndez <\/li>\n<li>eduardo Salido ruiz (vocal)<\/li>\n<li>Mar\u00eda  candelaria Garcia castro (vocal)<\/li>\n<li>jordi Xercavins montosa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Delia Garcia Marrero Introducci\u00f3n. Existen gran cantidad de factores pron\u00f3sticos establecidos en el c\u00e1ncer epitelial de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9915,347],"tags":[52658,41165,10554,207164,154655,207163],"class_list":["post-102049","post","type-post","status-publish","format-standard","hentry","category-la-laguna","category-oncologia-clinica","tag-eduardo-salido-ruiz","tag-francisco-javier-santolaria-fernandez","tag-jordi-xercavins-montosa","tag-jose-norberto-batista-lopez","tag-maria-candelaria-garcia-castro","tag-rosa-delia-garcia-marrero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102049"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102049\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}