{"id":102072,"date":"2018-03-11T10:24:06","date_gmt":"2018-03-11T10:24:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/theoretical-characterization-of-pentacovalent-oxyphosphorane-intermediate-structures-of-the-hydrolysis-of-rna-catalyzed-by-rnase-a\/"},"modified":"2018-03-11T10:24:06","modified_gmt":"2018-03-11T10:24:06","slug":"theoretical-characterization-of-pentacovalent-oxyphosphorane-intermediate-structures-of-the-hydrolysis-of-rna-catalyzed-by-rnase-a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/theoretical-characterization-of-pentacovalent-oxyphosphorane-intermediate-structures-of-the-hydrolysis-of-rna-catalyzed-by-rnase-a\/","title":{"rendered":"Theoretical characterization of pentacovalent oxyphosphorane intermediate structures of the hydrolysis of rna catalyzed by rnase a"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Formoso Estensoro <\/strong><\/h2>\n<p>En el presente proyecto hacemos uso de m\u00e9todos te\u00f3ricos para el an\u00e1lisis y caracterizaci\u00f3n de los mecanismos de reacci\u00f3n de hidr\u00f3lisis del enlace fosfodiester en mol\u00e9culas de arn, y as\u00ed mismo, el an\u00e1lisis del proceso catal\u00edtico llevado a cabo por la enzima rnasa a. utilizando bien m\u00e9todos cl\u00e1sicos o m\u00e9todos h\u00edbridos qm\/mm caracterizamos las estructuras intermedias formadas en la reacci\u00f3n de hidr\u00f3lisis del arn catalizada por la rnasa a, los oxifosforanos pentacovalentes. Analizamos el estado de protonaci\u00f3n de estos intermedios, y como var\u00edan sus interacciones con el entorno y el disolvente dependiendo de la protonaci\u00f3n. adem\u00e1s tomando varias coordenadas de reacci\u00f3n, analizamos diferentes perfiles energ\u00e9ticos de este proceso catal\u00edtico y analizamos diferentes mecanismos propuestos en la formaci\u00f3n de los intermedios oxifosforanos pentacovalentes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Theoretical characterization of pentacovalent oxyphosphorane intermediate structures of the hydrolysis of rna catalyzed by rnase a<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Theoretical characterization of pentacovalent oxyphosphorane intermediate structures of the hydrolysis of rna catalyzed by rnase a <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Formoso Estensoro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Javier Lopez Pesta\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: darrin m. York <\/li>\n<li>elixabete Rezabal astigarraga (vocal)<\/li>\n<li>annik Dejaegere (vocal)<\/li>\n<li>rita Guedes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Formoso Estensoro En el presente proyecto hacemos uso de m\u00e9todos te\u00f3ricos para el an\u00e1lisis y caracterizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909,17],"tags":[207204,207203,207201,136926,207202,207205],"class_list":["post-102072","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","category-quimica","tag-annik-dejaegere","tag-darrin-m-york","tag-elena-formoso-estensoro","tag-elixabete-rezabal-astigarraga","tag-jose-javier-lopez-pestana","tag-rita-guedes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102072"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102072\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}