{"id":102096,"date":"2018-03-11T10:24:06","date_gmt":"2018-03-11T10:24:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-molecular-del-mecanismo-de-resistencia-a-la-actividad-bactericida-del-suero-en-aislados-cla%c2%adnicos-de-neisseria-meningitidis-serogrupo-c\/"},"modified":"2018-03-11T10:24:06","modified_gmt":"2018-03-11T10:24:06","slug":"identificacion-y-caracterizacion-molecular-del-mecanismo-de-resistencia-a-la-actividad-bactericida-del-suero-en-aislados-cla%c2%adnicos-de-neisseria-meningitidis-serogrupo-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-molecular-del-mecanismo-de-resistencia-a-la-actividad-bactericida-del-suero-en-aislados-cla%c2%adnicos-de-neisseria-meningitidis-serogrupo-c\/","title":{"rendered":"Identificaci\u00f3n y caracterizaci\u00f3n molecular del mecanismo de resistencia a la actividad bactericida del suero en aislados cl\u00ednicos de neisseria meningitidis serogrupo c."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jose Uria Gonzalez <\/strong><\/h2>\n<p>El \u00e9xito obtenido con la implantaci\u00f3n de las vacunas conjugadas frente a neisseria meningitidis serogrupo c (menc) podr\u00eda verse afectado por la emergencia de cepas resistentes a la acci\u00f3n bactericida del suero. La presencia de anticuerpos bactericida s del suero (sba) es un par\u00e1metro subrogado de protecci\u00f3n frente a la infecci\u00f3n sist\u00e9mica por n. Meningitidis. En la presente tesis doctoral se han identificado tres cepas de menc, aisladas de pacientes con enfermedad meningoc\u00f3cica invasiva, resisten tes a la acci\u00f3n bactericida de sueros procedentes de individuos inmunizados con vacuna conjugada frente a menc. Cambios en el estado de la acetilaci\u00f3n del polisac\u00e1rido capsular y en el grado de sializaci\u00f3n del lipopolisac\u00e1rido no se relacionaron con la resistencia de los aislados. El fenotipo resistente se debi\u00f3 a la presencia de la secuencia de inserci\u00f3n is1301, en la regi\u00f3n interg\u00e9nica entre los operones sia y ctr (rig sia-ctr), necesarios para la s\u00edntesis y el transporte del polisac\u00e1rido caps ular. La inserci\u00f3n de is1301 produjo un aumento en los niveles de transcripci\u00f3n de los genes siaa y ctra, originando una mayor expresi\u00f3n de c\u00e1psula en todas las cepas. La mayor producci\u00f3n de polisac\u00e1rido capsular, se asoci\u00f3 con la inhibici\u00f3n de la ac tivaci\u00f3n de la v\u00eda alternativa del complemento, originando un mecanismo gen\u00e9rico por el que la bacteria se protege de la acci\u00f3n de anticuerpos bactericidas. Adem\u00e1s, las cepas con la secuencia is1301 en la rig sia-ctr evitaron la lisis en presencia de  anticuerpos bactericidas frente a otros ant\u00edgenos subcapsulares, incrementando la eficiencia de la resistencia en estas cepas. La caracterizaci\u00f3n del mecanismo de resistencia ha permitido desarrollar un m\u00e9todo basado en pcr para la detecci\u00f3n de este  tipo de aislados en estudios poblacionales, aplic\u00e1ndose en la presente tesis al estudio de cepas aisladas de fallos vacunales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n y caracterizaci\u00f3n molecular del mecanismo de resistencia a la actividad bactericida del suero en aislados cl\u00ednicos de neisseria meningitidis serogrupo c.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n y caracterizaci\u00f3n molecular del mecanismo de resistencia a la actividad bactericida del suero en aislados cl\u00ednicos de neisseria meningitidis serogrupo c. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jose Uria Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio A. V\u00e1zquez Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepcion Gil garcia <\/li>\n<li>Alberto Delgado iribarren (vocal)<\/li>\n<li>ernesto \u00e1ngel Garc\u00eda l\u00f3pez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Melero fondevilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jose Uria Gonzalez El \u00e9xito obtenido con la implantaci\u00f3n de las vacunas conjugadas frente a neisseria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,1],"tags":[207244,50945,67259,14396,21267,207243],"class_list":["post-102096","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-sin-categoria","tag-alberto-delgado-iribarren","tag-concepcion-gil-garcia","tag-ernesto-angel-garcia-lopez","tag-jose-antonio-melero-fondevilla","tag-julio-a-vazquez-moreno","tag-maria-jose-uria-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102096"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102096\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}