{"id":10214,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/sintesis-y-estudios-de-estructura-actividad-de-peptidos-antibacterianos-derivados-de-cecropina-a-y-melitina\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"sintesis-y-estudios-de-estructura-actividad-de-peptidos-antibacterianos-derivados-de-cecropina-a-y-melitina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-estudios-de-estructura-actividad-de-peptidos-antibacterianos-derivados-de-cecropina-a-y-melitina\/","title":{"rendered":"Sintesis y estudios de estructura-actividad de peptidos antibacterianos derivados de cecropina-a y melitina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Ubach Cartategui <\/strong><\/h2>\n<p>En el presente trabajo se ha abordado el estudio de los peptidos como futuros agentes antibacterianos. En concreto, el trabajo se ha realizado con peptidos provenientes yuxtaponer parte de las secuencias polipeptidicas de dos peptidos naturales con elevada actividad antibacteriana, cecropina-a y melitina.  empleando tecnicas de sintesis en fase solida se han sintetizado diversas estructuras peptidicas de entre 11 y 15 aminoacidos que presentan un amplio espectro antibacteriano y una elevada potencia de accion. Estas nuevas estructuras hibridas suponen una importante reduccion respecto a la talla de los peptidos parentales, cecropina-a y melitina, de 37 y 26 aminoacidos respectivamente. Los factores estructurales que parecen responsables de la elevada actividad de estos peptidos son: i) elevada composicion en aminoacidos cationicos en la region n-terminal, ii) region c-terminal con elevada composicion en aminoacidos hidrofobicos como valina y leucina, iii) capacidad para adoptar estructuras -helicoidales, iv) distribucion anfipatica de los aminoacidos dentro de la helice-, v) tendencia a formar agregados entre diferentes moleculas de peptido para la formacion de poros en la membrana bacteriana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y estudios de estructura-actividad de peptidos antibacterianos derivados de cecropina-a y melitina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y estudios de estructura-actividad de peptidos antibacterianos derivados de cecropina-a y melitina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Ubach Cartategui <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Andreu Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ernest Giralt Lledo <\/li>\n<li>Luis Rivas L\u00f3pez (vocal)<\/li>\n<li>Sergi Erill Saez (vocal)<\/li>\n<li>Enrique Perez Paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Ubach Cartategui En el presente trabajo se ha abordado el estudio de los peptidos como futuros [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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