{"id":102156,"date":"2018-03-11T10:24:12","date_gmt":"2018-03-11T10:24:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-factores-epigeneticos-en-el-cancer-papilar-de-tiroides-y-su-correlacion-cla%c2%adnica\/"},"modified":"2018-03-11T10:24:12","modified_gmt":"2018-03-11T10:24:12","slug":"identificacion-de-factores-epigeneticos-en-el-cancer-papilar-de-tiroides-y-su-correlacion-cla%c2%adnica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-factores-epigeneticos-en-el-cancer-papilar-de-tiroides-y-su-correlacion-cla%c2%adnica\/","title":{"rendered":"Identificaci\u00f3n de factores epigen\u00e9ticos en el cancer papilar de tir\u00f3ides y su correlaci\u00f3n cl\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Hidalgo Garcia <\/strong><\/h2>\n<p>Introducci\u00f3n: las lesiones malignas del tiroides se han relacionado siempre con alteraciones funcionales y metab\u00f3licas. Sin embargo, los estudios de variaciones gen\u00e9ticas pueden tener una relaci\u00f3n directa con el c\u00e1ncer de tiroides. Este estudio prete nde investigar si existen alteraciones en el adn que puedan estar relacionadas con el c\u00e1ncer papilar de tiroides.  material y m\u00e9todo: a 41 pacientes con c\u00e1ncer papilar de tiroides intervenidos quir\u00fargicamente, se les ha realizado extracci\u00f3n de adn me diante un procedimiento de pirosecuenciaci\u00f3n, se han estudiado diferentes genes del brazo largo del cromosoma 11, en una regi\u00f3n donde previamente se ha puesto de manifiesto que exist\u00edan alteraciones gen\u00e9ticas relacionadas con el c\u00e1ncer de mama y de o vario. Se han estudiado 9 marcadores polim\u00f3rficos de los genes emsy, pak1, y capn5. As\u00ed mismo, se ha realizado una correlaci\u00f3n cl\u00ednica entre las alteraciones encontradas y la historia cl\u00ednica de los pacientes.  resultados: hemos encontrado los siguie ntes hallazgos: no se ha encontrado existencia de desajuste al\u00e9lico en los genes estudiados respecto al c\u00e1ncer papilar de tiroides; no hay indicios de que los polimorfismos estudiados influyan en el riesgo de padecer estos tumores; el haplotipo 111 d el gen emsy est\u00e1 m\u00e1s representado, por lo que podr\u00eda conferir cierta predisposici\u00f3n gen\u00e9tica al c\u00e1ncer papilar de tiroides.  conclusiones: la paaf es un m\u00e9todo diagn\u00f3stico v\u00e1lido en patolog\u00eda tiroidea; en el carcinoma papilar de tiroides el procedimi ento quir\u00fargico de elecci\u00f3n es, casi siempre, la tiroidectom\u00eda total; se ha conseguido optimizar el protocolo de extracci\u00f3n de adn; la pirosecuenciaci\u00f3n es un m\u00e9todo eficaz para la cuantificaci\u00f3n al\u00e9licas y estudio de p\u00e9rdidas de heterocigosidad; se han analizado 9 marcadores en los genes emsy, pak1 y capn5 sin evidenciarse p\u00e9rdida de heterocigosidad; la regi\u00f3n cromos\u00f3mica 11q13q-14 donde se encuentran estos genes, no sufre desajuste al\u00e9lico; el haplotipo 111 del gen emsy est\u00e1 excesivamente repr esentado en los pacientes con c\u00e1ncer papilar de tiroides, lo cual podr\u00eda tener relevancia en la etiolog\u00eda del mismo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de factores epigen\u00e9ticos en el cancer papilar de tir\u00f3ides y su correlaci\u00f3n cl\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de factores epigen\u00e9ticos en el cancer papilar de tir\u00f3ides y su correlaci\u00f3n cl\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Hidalgo Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Ferrero Herrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas \u00e1lvarez fern\u00e1ndez-represa <\/li>\n<li>Jos\u00e9 Manuel Figueroa andollo (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ortega bevia (vocal)<\/li>\n<li>eduardo enrique Rubio gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Hidalgo Garcia Introducci\u00f3n: las lesiones malignas del tiroides se han relacionado siempre con alteraciones funcionales y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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