{"id":102167,"date":"2018-03-11T10:24:16","date_gmt":"2018-03-11T10:24:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/scarface-a-secreted-serine-protease-like-protein-regulates-polarized-localization-of-laminin-a-at-the-basement-membrane-of-the-drosophila-embryo\/"},"modified":"2018-03-11T10:24:16","modified_gmt":"2018-03-11T10:24:16","slug":"scarface-a-secreted-serine-protease-like-protein-regulates-polarized-localization-of-laminin-a-at-the-basement-membrane-of-the-drosophila-embryo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/scarface-a-secreted-serine-protease-like-protein-regulates-polarized-localization-of-laminin-a-at-the-basement-membrane-of-the-drosophila-embryo\/","title":{"rendered":"Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin a at the basement membrane of the drosophila embryo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Georgina Sorrosal De Luna <\/strong><\/h2>\n<p>Cell-matrix interactions brought about by the activity of integrins and laminins maintain the polarized architecture of epithelia and mediate morphogenetic interactions between apposing tissues. Although the polarized localization of laminins at the basement membrane is a crucial step in these processes, little is known about how this polarized distribution is achieved. Here we analyzed in drosophila the role of the secreted serine-protease like protein scarface in germ band retraction and dorsal closure, morphogenetic processes that rely on the activity of integrins and laminins. We present evidence that scarface is regulated by jnk and that scarface mutant embryos show defects in these morphogenetic processes. Anomalous accumulation of laminin a on the apical surface of epithelial cells is observed in these embryos and this happened prior to inducing loss of epithelial polarity. We propose that scarface plays a key role in regulating the polarized localization of laminin a in this developmental context.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin a at the basement membrane of the drosophila embryo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin a at the basement membrane of the drosophila embryo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Georgina Sorrosal De Luna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marco Milan Kalbfleisch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gerardo Jim\u00e9nez ca\u00f1ero <\/li>\n<li>Mar\u00eda dolores Mart\u00edn bermudo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Georgina Sorrosal De Luna Cell-matrix interactions brought about by the activity of integrins and laminins maintain the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,962,2119],"tags":[207364,126579,140911,69139],"class_list":["post-102167","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-genetica","category-genetica-animal","tag-georgina-sorrosal-de-luna","tag-gerardo-jimenez-canero","tag-marco-milan-kalbfleisch","tag-maria-dolores-martin-bermudo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102167"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102167\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}