{"id":102212,"date":"2018-03-11T10:24:16","date_gmt":"2018-03-11T10:24:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-generadores-de-la-actividad-beta-subtalamica-y-otras-oscilaciones-anomalas-de-los-basales-papel-en-la-fisiopatologa%c2%ada-de-la-enfermedad-de-parkinson\/"},"modified":"2018-03-11T10:24:16","modified_gmt":"2018-03-11T10:24:16","slug":"mecanismos-generadores-de-la-actividad-beta-subtalamica-y-otras-oscilaciones-anomalas-de-los-basales-papel-en-la-fisiopatologa%c2%ada-de-la-enfermedad-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurofisiologia-humana\/mecanismos-generadores-de-la-actividad-beta-subtalamica-y-otras-oscilaciones-anomalas-de-los-basales-papel-en-la-fisiopatologa%c2%ada-de-la-enfermedad-de-parkinson\/","title":{"rendered":"Mecanismos generadores de la actividad beta subtal\u00e1mica y otras oscilaciones an\u00f3malas de los basales. papel en la fisiopatolog\u00eda de la enfermedad de parkinson."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Jes\u00fas Nicol\u00e1s Apestegu\u00eda <\/strong><\/h2>\n<p>We studied the oscillatory activity from different nuclei from basal ganglia and motor cortex in both control and 6-ohda lesioned rats as a model of parkinson disease.   we recorded local field potentials from the motor cortex, subthalamic area, caudate-putamen and substantia nigra pars reticulate in basal conditions and under pharmacological stimulation of three different drugs: apomorphine (dopaminergic agonist), haloperidol (dopaminergic antagonist) and ketamina (nmda).   6-ohda lesioned rats show abnormal beta activity in basal ganglia and motor cortex, which is reduced after apomorphine administration. Despite of some differences in amplitudes, apomorphine also induced two peaks of activity in the gamma range (around 45 and 85hz) in both groups.   ketamine administration increased the power of the oscillatory activity at different frequencies. Nevertheless, the most prominent increase was observed for high frequencies, in the range of 140-160hz. This activity also showed a high correlation with the motor activity of the animals.  the most important finding in this work was the observation of changes in the fractal properties of the oscillatory activity due to pharmacological stimulation\/6-ohda lesion. The power spectrum showed an 1\/f characteristic trend, resulting in an inverse linear relation between log power and log frequency. While the slope of this trend (scaling exponent) was increased by chronic (6-ohda) or acute (haloperidol) blockage of dopaminergic system, apomorphine administration increased this value.   these results suggest that not only the irruption of novel activities but also the modification of other features of the oscillatory activity could play an important role in the physiopathology of pd.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos generadores de la actividad beta subtal\u00e1mica y otras oscilaciones an\u00f3malas de los basales. papel en la fisiopatolog\u00eda de la enfermedad de parkinson.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos generadores de la actividad beta subtal\u00e1mica y otras oscilaciones an\u00f3malas de los basales. papel en la fisiopatolog\u00eda de la enfermedad de parkinson. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Jes\u00fas Nicol\u00e1s Apestegu\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Artieda Gonzalez Granda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>Jorge Iriarte franco (vocal)<\/li>\n<li>gabriela Goizueta san mart\u00edn (vocal)<\/li>\n<li>marc stefan Dawid milner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jes\u00fas Nicol\u00e1s Apestegu\u00eda We studied the oscillatory activity from different nuclei from basal ganglia and motor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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