{"id":102222,"date":"2018-03-11T10:24:20","date_gmt":"2018-03-11T10:24:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-mediante-microscopa%c2%ada-electronica-del-complejo-xrcc4-dna-ligasa-iv-implicado-en-reparacion-de-roturas-del-dna\/"},"modified":"2018-03-11T10:24:20","modified_gmt":"2018-03-11T10:24:20","slug":"caracterizacion-estructural-mediante-microscopa%c2%ada-electronica-del-complejo-xrcc4-dna-ligasa-iv-implicado-en-reparacion-de-roturas-del-dna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-mediante-microscopa%c2%ada-electronica-del-complejo-xrcc4-dna-ligasa-iv-implicado-en-reparacion-de-roturas-del-dna\/","title":{"rendered":"Caracterizaci\u00f3n estructural mediante microscop\u00edaelectr\u00f3nica del complejo xrcc4-dna ligasa iv, implicado en reparaci\u00f3n de roturas del dna."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Angeles Recuero Checa <\/strong><\/h2>\n<p>Las c\u00e9lulas de cualquier organismo vivo est\u00e1n sometidas a multitud de amenazas tanto ex\u00f3genas como end\u00f3genas que pueden da\u00f1ar el genoma. Existen diversos tipos de roturas en el dna, siendo las roturas de doble cadena unas de las m\u00e1s peligrosas para l a supervivencia celular. En eucariotas superiores, estas roturas son reparadas principalmente mediante el mecanismo de reparaci\u00f3n de uni\u00f3n de extremos no hom\u00f3logos (tambi\u00e9n llamado nhej, del ingl\u00e9s non-homologous end-joining), donde los extremos de d na son reparados sin utilizar para ello un molde. Durante el desarrollo de esta tesis se han estudiado el complejo de prote\u00ednas xrcc4-dna ligasa iv, as\u00ed como la prote\u00edna xlf que participan en esta ruta de reparaci\u00f3n de dna. El complejo xrcc4-dna liga sa iv es el responsable de llevar a cabo el proceso de ligaci\u00f3n de los dos fragmentos de dna generados en el punto de rotura, mientras que la prote\u00edna xlf interviene en el proceso cuando el dna adopta determinadas configuraciones tras la rotura. \u00fanic amente existe informaci\u00f3n estructural de dominios aislados de estas prote\u00ednas, mientras que la estructura de las prote\u00ednas completas y c\u00f3mo se organizan en el complejo se desconocen en la actualidad. El objetivo principal ha sido la determinaci\u00f3n est ructural de la prote\u00edna xrcc4 y del complejo xrcc4-dna ligasa iv mediante microscop\u00eda electr\u00f3nica de transmisi\u00f3n y an\u00e1lisis de part\u00edculas individuales. Se ha visualizado por primera vez y resuelto la estructura de la prote\u00edna xrcc4 completa, as\u00ed como  del complejo xrcc4-dna ligasa iv. En conjunto, los estudios realizados nos han permitido proponer un modelo para la organizaci\u00f3n tridimensional de este complejo y su uni\u00f3n a dna. Por otro lado, se han llevado a cabo estudios preliminares de la inter acci\u00f3n de la prote\u00edna xlf con el complejo xrcc4-dna ligasa iv con el objetivo de seguir profundizando en el estudio de este mecanismo de reparaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n estructural mediante microscop\u00edaelectr\u00f3nica del complejo xrcc4-dna ligasa iv, implicado en reparaci\u00f3n de roturas del dna.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n estructural mediante microscop\u00edaelectr\u00f3nica del complejo xrcc4-dna ligasa iv, implicado en reparaci\u00f3n de roturas del dna. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Angeles Recuero Checa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar Llorca Blanco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Perez gil <\/li>\n<li>Jaime Mart\u00edn-benito romero (vocal)<\/li>\n<li>Santiago Ramon maiques (vocal)<\/li>\n<li>daniel Luque buzo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Angeles Recuero Checa Las c\u00e9lulas de cualquier organismo vivo est\u00e1n sometidas a multitud de amenazas tanto 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