{"id":102262,"date":"2018-03-11T10:24:20","date_gmt":"2018-03-11T10:24:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-fosfocalcico-en-mamiferos-con-hipercalcemia-fisiologica-influencia-de-la-insuficiencia-renal-cronica\/"},"modified":"2018-03-11T10:24:20","modified_gmt":"2018-03-11T10:24:20","slug":"metabolismo-fosfocalcico-en-mamiferos-con-hipercalcemia-fisiologica-influencia-de-la-insuficiencia-renal-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/nefrologia\/metabolismo-fosfocalcico-en-mamiferos-con-hipercalcemia-fisiologica-influencia-de-la-insuficiencia-renal-cronica\/","title":{"rendered":"Metabolismo fosfocalcico en mamiferos con hipercalcemia fisiologica: influencia de la insuficiencia renal cronica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Bas Izquierdo <\/strong><\/h2>\n<p>En esta tesis se ha investigado la din\u00e1mica de secreci\u00f3n de hormona paratiroidea (pth) y el hiperparatiroidismo secundario (hpt2) utilizando el conejo, una especie con hipercalc\u00e9mia fisiol\u00f3gica, como modelo animal de experimentaci\u00f3n.   en primer lugar, se ha estudiado el efecto de la hipercalcemia aguda y cr\u00f3nica sobre la respuesta secretora de pth a la posterior hipocalcemia. La hipercalcemia aguda provoca una repuesta atenuada de pth a la hipocalcemia que depende del grado y tiempo de la hipercalcemia que la precede. En cambio, el proceso cr\u00f3nico no altera la posterior respuesta hipocalc\u00e9mica.  se ha evaluado, adem\u00e1s, la funci\u00f3n paratiroidea en conejos ur\u00e9micos alimentados con dietas de diferente contenido en calcio y f\u00f3sforo observando que los conejos ur\u00e9micos alimentados con una dieta est\u00e1ndar (ca 1.2%, p 0.6%) desarrollan hipercalcemia, disminuci\u00f3n de la secreci\u00f3n de pth y una relaci\u00f3n pth-ca+2 comparable a los conejos normales. Los conejos ur\u00e9micos alimentados con dieta baja en ca y alta en p, dbcaap (ca 0.6%, p 1.2%), desarrollan hipocalcemia e hpt2 y disminuye el set point de la curva pth-ca+2. Se estudia la evoluci\u00f3n del hpt y se observa un incremento en el tama\u00f1o de la gl\u00e1ndula, en la tasa de proliferaci\u00f3n y en la expresi\u00f3n del receptor de calcio.   por \u00faltimo, se ha investigado las causas y el desarrollo del hpt secundario de origen nutricional en  conejos alimentados con dbcaap. Estos animales desarrollan r\u00e1pidamente hpt2 aunque menos acentuado que los conejos ur\u00e9micos, a pesar de presentar el mismo grado de hipocalcemia. Este grupo presenta una evoluci\u00f3n similar del set point de la curva pth- ca+2. Las gl\u00e1ndulas paratiroides de estos animales sufren alteraciones similares a las observadas en el grupo de animales ur\u00e9micos con hpt2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo fosfocalcico en mamiferos con hipercalcemia fisiologica: influencia de la insuficiencia renal cronica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo fosfocalcico en mamiferos con hipercalcemia fisiologica: influencia de la insuficiencia renal cronica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Bas Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Escolastico Aguilera Tejero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Gomez villamandos <\/li>\n<li>victor Sorribas alejandre (vocal)<\/li>\n<li>eduard Jos\u00e9  cunilleras (vocal)<\/li>\n<li>yolanda Almaden pe\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Bas Izquierdo En esta tesis se ha investigado la din\u00e1mica de secreci\u00f3n de hormona paratiroidea (pth) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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