{"id":102339,"date":"2010-02-07T00:00:00","date_gmt":"2010-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-un-nuevo-modelo-de-carcinogenesis-pulmonar-en-raton-mediado-por-dimetilnitrosamina-e-inflamacion-cronica\/"},"modified":"2010-02-07T00:00:00","modified_gmt":"2010-02-07T00:00:00","slug":"desarrollo-y-caracterizacion-de-un-nuevo-modelo-de-carcinogenesis-pulmonar-en-raton-mediado-por-dimetilnitrosamina-e-inflamacion-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/desarrollo-y-caracterizacion-de-un-nuevo-modelo-de-carcinogenesis-pulmonar-en-raton-mediado-por-dimetilnitrosamina-e-inflamacion-cronica\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n de un nuevo modelo de carcinog\u00e9nesis pulmonar en rat\u00f3n mediado por dimetilnitrosamina e inflamaci\u00f3n cr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Freire Salinas <\/strong><\/h2>\n<p>Lung cancer is the first cause of cancer deaths over the world. There is a  growing body of evidence that inflammation plays a central role in lung carcinogenesis many aspects of the epidemiologic association between lung chronic inflammatory conditions such as chronic obstructive pulmonary disease have not been adequately investigated due to lack of appropriate animal models. In the present thesis we have generated a new model of lung carcinogenesis initiated by a tobacco carcinogen, dimethylnitrosamine (dmna), and promoted by a chronic inflammatory process caused by crystalline silica. a single oropharingeal instillation of silica crystals significantly increased the incidence and multiplicity of tumor lesions caused by dmna. This combined model showed type-2 pneumocyte and neuroendocrine cell hyperplasia. Plasma levels of tnf-\u00e1, mip-1\u00e1 and ip10 were elevated at 2,4,6, 9 and 12 months after treatment, except for tnf-\u00e1 levels which were normal at 12 months,  a microarray gene expression study showed that the main differences found between the both treatments were observed in adenomas rather than in adenocarcinomas. We also showed that the pattern of kras mutations was associated with the type of treatment received: g12d in the combined protocol and q61r in the group which was treated with dmna only. In addition, in order to validate the data generated by this new model, we isolated and characterized two adenocarcinoma cell lines. our data clearly support that chronic inflammation promotes lung carcinogenesis in a balb\/c mouse model and that the chronic inflammation promoted tumors show specific molecular features.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n de un nuevo modelo de carcinog\u00e9nesis pulmonar en rat\u00f3n mediado por dimetilnitrosamina e inflamaci\u00f3n cr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n de un nuevo modelo de carcinog\u00e9nesis pulmonar en rat\u00f3n mediado por dimetilnitrosamina e inflamaci\u00f3n cr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Freire Salinas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Montuenga Badia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco jose Saez crespo <\/li>\n<li>alfredo Mart\u00ednez ram\u00edrez (vocal)<\/li>\n<li>Jos\u00e9 Javier Gomez roman (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Hermida santos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Freire Salinas Lung cancer is the first cause of cancer deaths over the world. There [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,52,17749,1027],"tags":[83215,207641,146955,26316,74560,17856],"class_list":["post-102339","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-histopatologia","category-navarra","category-oncologia","tag-alfredo-Martinez-ramirez","tag-francisco-javier-freire-salinas","tag-francisco-jose-saez-crespo","tag-jose-javier-gomez-roman","tag-jose-maria-hermida-santos","tag-luis-montuenga-badia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102339"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102339\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102339"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}