{"id":102340,"date":"2010-02-07T00:00:00","date_gmt":"2010-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-nanoparta%c2%adculas-de-gantrez-an-119-con-ciclosporina-a-para-administracion-oral-comportamiento-in-vivo\/"},"modified":"2010-02-07T00:00:00","modified_gmt":"2010-02-07T00:00:00","slug":"desarrollo-y-caracterizacion-de-nanoparta%c2%adculas-de-gantrez-an-119-con-ciclosporina-a-para-administracion-oral-comportamiento-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/desarrollo-y-caracterizacion-de-nanoparta%c2%adculas-de-gantrez-an-119-con-ciclosporina-a-para-administracion-oral-comportamiento-in-vivo\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n de nanopart\u00edculas de gantrez an 119 con ciclosporina a para administraci\u00f3n oral. comportamiento in vivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marisin Pecchio Gonz\u00e1lez <\/strong><\/h2>\n<p>Cyclosporine a has been widely used because it is a potent immuno-suppressive agent, however it present low bioavailability and many problems to be formulated. Thus, we have developed 13 new formulations for this drug in gantrez\u00c2\u00ae an 119 nanoparticles, which one expects to be alternative to those currently available commercial. Four formulations were optimized, those had the most interesting properties, and then we selected three to study their in vivo behaviour in rat. Our results show those three formulations could be alternatives to the commercial formulation sandimmun neoral\u00c2\u00ae for oral administration of cyclosporine a. In view of the result, the formulation c(17.5) is probably the best because when cyclosporine is administered in this formulation we has been found drug bioavailability in magnitude increase 21.43% that when the drug is administrated in the oral formulation sandimmun neoral\u00c2\u00ae, on the other hand when the drug is administrated in formulations e(12.5) and g(15) cyclosporine bioavailability is similar to the one which presents commercial formulation. Finally, the time needed to reach maximum blood concentration for three formulations developed is greater than the one corresponding to the commercial formulation, resulting in sustained drug levels.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n de nanopart\u00edculas de gantrez an 119 con ciclosporina a para administraci\u00f3n oral. comportamiento in vivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n de nanopart\u00edculas de gantrez an 119 con ciclosporina a para administraci\u00f3n oral. comportamiento in vivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marisin Pecchio Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Dios Vi\u00e9itez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  manuel Irache garreta <\/li>\n<li>M\u00aa bego\u00f1a Calvo hernaez (vocal)<\/li>\n<li>elvira Escribano ferrer (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Garc\u00eda celma (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marisin Pecchio Gonz\u00e1lez Cyclosporine a has been widely used because it is a potent immuno-suppressive agent, however [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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