{"id":102420,"date":"2010-02-07T00:00:00","date_gmt":"2010-02-07T00:00:00","guid":{"rendered":""},"modified":"2010-02-07T00:00:00","modified_gmt":"2010-02-07T00:00:00","slug":"factores-geneticos-asociados-con-predisposicion-a-lupus-eritematoso-sistemico-confirmacion-efecto-funcional-repercusion-fenota%c2%adpica-y-relacion-con-la-susceptibilidad-a-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/factores-geneticos-asociados-con-predisposicion-a-lupus-eritematoso-sistemico-confirmacion-efecto-funcional-repercusion-fenota%c2%adpica-y-relacion-con-la-susceptibilidad-a-la-artritis-reumatoide\/","title":{"rendered":"Factores gen\u00e9ticos asociados con predisposici\u00f3n a lupus eritematoso sist\u00e9mico: confirmaci\u00f3n, efecto funcional, repercusi\u00f3n fenot\u00edpica y relaci\u00f3n con la susceptibilidad a la artritis reumatoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda De Los  \u00e1ngeles Su\u00e1rez Gestal <\/strong><\/h2>\n<p>En funci\u00f3n de resultados recientes de gwas y otros estudios de asociaci\u00f3n en lupus eritematoso sist\u00e9mico (les), trataremos de confirmar nuevas se\u00f1ales de asociaci\u00f3n (itgam, kiaa1542, pxk, 1q25.1, blk-c8orf13, stat4, tyk2, bank1, mecp2-irak1 y ly9) en una cohorte de muestras de les independiente, mediante la estrategia de los estudios de asociaci\u00f3n caso-control. Tambi\u00e9n intentaremos buscar una explicaci\u00f3n a la heterogeneidad cl\u00ednica del les y trataremos de evaluar si la interacci\u00f3n entre genes asociados individualmente con la enfermedad puede aumentar el riesgo de sufrirla. En funci\u00f3n de los resultados que se obtengan a partir de los estudios gen\u00e9ticos realizados en el gen pdcd1 se llevar\u00e1n a cabo estudios funcionales de aquellos polimorfismos que muestren una asociaci\u00f3n significativa con les. Para ello utilizaremos ensayos de cambio de movilidad electrofor\u00e9tica (emsa, electrophoretic mobility shift assay) y de gen reporter. Como los estudios de asociaci\u00f3n llevados a cabo en otras enfermedades autoinmunes sugirieron la posibilidad de que compartan parte de su componente gen\u00e9tico, exploraremos, tambi\u00e9n mediante un estudio de asociaci\u00f3n caso-control, qu\u00e9 factores gen\u00e9ticos comparten el les y la artritis reumatoide.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores gen\u00e9ticos asociados con predisposici\u00f3n a lupus eritematoso sist\u00e9mico: confirmaci\u00f3n, efecto funcional, repercusi\u00f3n fenot\u00edpica y relaci\u00f3n con la susceptibilidad a la artritis reumatoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores gen\u00e9ticos asociados con predisposici\u00f3n a lupus eritematoso sist\u00e9mico: confirmaci\u00f3n, efecto funcional, repercusi\u00f3n fenot\u00edpica y relaci\u00f3n con la susceptibilidad a la artritis reumatoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda De Los  \u00e1ngeles Su\u00e1rez Gestal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>pedrayo Gonz\u00e1lez Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  victoria Lareu huidobro <\/li>\n<li>Mar\u00eda Galindo izquierdo (vocal)<\/li>\n<li>Jaime Calvo alen (vocal)<\/li>\n<li>gonzalo \u00e1lvarez jurado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda De Los \u00e1ngeles Su\u00e1rez Gestal En funci\u00f3n de resultados recientes de gwas y otros estudios de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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