{"id":102447,"date":"2010-05-07T00:00:00","date_gmt":"2010-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lyp-una-fosfatasa-de-tirosina-implicada-en-enfermedades-autoinmunes\/"},"modified":"2010-05-07T00:00:00","modified_gmt":"2010-05-07T00:00:00","slug":"lyp-una-fosfatasa-de-tirosina-implicada-en-enfermedades-autoinmunes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/lyp-una-fosfatasa-de-tirosina-implicada-en-enfermedades-autoinmunes\/","title":{"rendered":"Lyp, una fosfatasa de tirosina implicada en enfermedades autoinmunes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa Luisa De La Puerta Turrillas <\/strong><\/h2>\n<p>La realizaci\u00f3n de esta tesis doctoral se ha centrado en el estudio de la fosfatasa de tirosinas lyp (lymphoid tyrosine phosphatase) codificada por el gen ptpn22 situado en el cromosoma 1p13.3-13.1. Su ort\u00f3logo en el rat\u00f3n fue aislado en 1992  con el nombre de pep (pest enriched phosphatase). Un polimorfismo de un nucle\u00f3tido (single nucleotide polymorphism, snp) que produce un cambio en la posici\u00f3n 620 de r a w est\u00e1 asociado a enfermedades autoinmunes: t1d, artritis reumatoide, lupus sist\u00e9mico diseminado, enfermedad de graves, artritis juvenil idiop\u00e1tica; enfermedad de addison  y tiroiditis de hashimoto . Sin embargo, el alelo w620 de lyp no confiere riesgo de padecer otras enfermedades autoinmunes, como esclerosis multiple, colangitis esclerosante primaria, enfermedad de chron o psoriasis. Estos datos sugieren la existencia de un mecanismo com\u00fan en la etiolog\u00eda de las enfermedades autoinmunes en las que lyp w620 es un factor de riesgo.   en resumen, aun sabemos muy poco acerca del modo de acci\u00f3n de lyp en las c\u00e9lulas del sistema inmune. Sin esa informaci\u00f3n es dif\u00edcil averiguar como el polimorfismo de lyp en la posici\u00f3n 620 contribuye a generar las enfermedades autoinmunes, informaci\u00f3n que creemos es necesaria para ser utilizada en la terape\u00fatica de estas enfermedades y de ah\u00ed su investigaci\u00f3n para la realizaci\u00f3n de esta memoria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lyp, una fosfatasa de tirosina implicada en enfermedades autoinmunes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lyp, una fosfatasa de tirosina implicada en enfermedades autoinmunes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa Luisa De La Puerta Turrillas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Yolanda Bay\u00f3n Prierto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Garc\u00eda rodr\u00edguez <\/li>\n<li>Jos\u00e9 Mar\u00eda De pereda (vocal)<\/li>\n<li>m. eugenia Fern\u00e1ndez santos (vocal)<\/li>\n<li>Rafael Pulido murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa Luisa De La Puerta Turrillas La realizaci\u00f3n de esta tesis doctoral se ha centrado en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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