{"id":102490,"date":"2010-05-07T00:00:00","date_gmt":"2010-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/filtros-opticos-contra-el-efecto-fototoxico-del-espectro-visible-en-la-retina-experimental-animal\/"},"modified":"2010-05-07T00:00:00","modified_gmt":"2010-05-07T00:00:00","slug":"filtros-opticos-contra-el-efecto-fototoxico-del-espectro-visible-en-la-retina-experimental-animal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/optica\/filtros-opticos-contra-el-efecto-fototoxico-del-espectro-visible-en-la-retina-experimental-animal\/","title":{"rendered":"Filtros \u00f3pticos contra el efecto fotot\u00f3xico del espectro visible en la retina: experimental animal"},"content":{"rendered":"

Tesis doctoral de Celia Sanchez Ramos <\/strong><\/h2>\n

Planteamiento: la luz de longitud de onda corta provoca un proceso neurodegenerativo en la retina que es menor si se emplean filtros \u00f3pticos selectivos que absorban esta radiaci\u00f3n. objetivos: – evaluar el efecto fotot\u00f3xico de la luz y la acci\u00f3n protectora contra las longitudes de onda corta de los filtros \u00f3pticos de absorbancia selectiva en la retina de animales de experimentaci\u00f3n. – objetivos espec\u00edficos: a) an\u00e1lisis estructural de la retina – comparar la densidad celular de las capas nuclear interna y externa de retinas de conejos expuestos a diferentes luces – determinar si la muerte celular se produce por apoptosis – determinar el tipo de fotorreceptor m\u00e1s afectado – valorar el efecto protector de las lentes intraoculares con filtro selectivo a la luz azul b) an\u00e1lisis de expresi\u00f3n g\u00e9nica – expresi\u00f3n g\u00e9nica de genes pro y anti-apopt\u00f3ticos a la luz – expresi\u00f3n g\u00e9nica de prote\u00ednas ligantes del calcio, trk, receptor bdnf, genes timp1 y timp2, y el posible efecto protector de los filtros – estudiar las metaloproteasas y contribuir al conocimiento de su regulaci\u00f3n en la degeneraci\u00f3n retiniana inducida por la luz. medios utilizados: conejos pigmentados (raza leonado de borgo\u00f1a) fueron sometidos a cirug\u00eda de cristalino mediante facoemulsificaci\u00f3n e implante de lentes intraoculares binocularmente: lente con pigmentaci\u00f3n amarilla (en ojo derecho), lente transparente (en ojo izquierdo). Los animales eran expuestos a luces de distintas caracter\u00edsticas (luz blanca, luz amarilla, luz azul) con un ritmo circadiano prolongado durante 2 a\u00f1os. se empleo un grupo control de animales no intervenidos, expuestos a los mismos tipos de iluminaci\u00f3n controlada. se analizaron las retinas de los animales de experimentaci\u00f3n mediante estudios estructurales, inmunohistoqu\u00edmicos y de expresi\u00f3n gen\u00e9tica. aportaciones originales: la exposici\u00f3n a una iluminaci\u00f3n circadiana prolongada produce una disminuci\u00f3n celular retiniana en las capas nucleares externa e interna. La luz azul produce mayor da\u00f1o celular, afectando especialmente a los fotorreceptores (bastones); estos efectos son parcialmente evitados utilizando filtros amarillos en la luz o en la lente intraocular implantada.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abFiltros \u00f3pticos contra el efecto fotot\u00f3xico del espectro visible en la retina: experimental animal<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Filtros \u00f3pticos contra el efecto fotot\u00f3xico del espectro visible en la retina: experimental animal <\/li>\n
  • Autor:<\/strong>\u00a0 Celia Sanchez Ramos <\/li>\n
  • Universidad:<\/strong>\u00a0 Europea de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Julian Garcia Sanchez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Jos\u00e9 manuel Ram\u00edrez sebasti\u00e1n <\/li>\n
        • catalina Palomo alvarez (vocal)<\/li>\n
        • Mar\u00eda Jes\u00fas P\u00e9rez carrasco (vocal)<\/li>\n
        • Alberto Trivi\u00f1o casado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Celia Sanchez Ramos Planteamiento: la luz de longitud de onda corta provoca un proceso neurodegenerativo en la […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[51447,1525],"tags":[7156,195685,7527,6445,756,126475],"class_list":["post-102490","post","type-post","status-publish","format-standard","hentry","category-europea-de-madrid","category-optica","tag-alberto-trivino-casado","tag-catalina-palomo-alvarez","tag-celia-sanchez-ramos","tag-jose-manuel-ramirez-sebastian","tag-julian-garcia-sanchez","tag-maria-jesus-perez-carrasco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=102490"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/102490\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=102490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=102490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=102490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}