{"id":102567,"date":"2010-07-07T00:00:00","date_gmt":"2010-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cualificacion-y-cuantificacion-de-hormonas-esteroideas-en-fluidos-biologicos-humanos-plasma-y-orina-mediante-gc-ms-gc-ms-ms-y-lc-ms\/"},"modified":"2010-07-07T00:00:00","modified_gmt":"2010-07-07T00:00:00","slug":"cualificacion-y-cuantificacion-de-hormonas-esteroideas-en-fluidos-biologicos-humanos-plasma-y-orina-mediante-gc-ms-gc-ms-ms-y-lc-ms","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-analitica\/cualificacion-y-cuantificacion-de-hormonas-esteroideas-en-fluidos-biologicos-humanos-plasma-y-orina-mediante-gc-ms-gc-ms-ms-y-lc-ms\/","title":{"rendered":"Cualificaci\u00f3n y cuantificaci\u00f3n de hormonas esteroideas en fluidos biol\u00f3gicos humanos (plasma y orina) mediante gc\/ms, gc\/ms-ms y lc\/ms."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Ferm\u00edn Toribio Delgado <\/strong><\/h2>\n<p>La valoraci\u00f3n hormonal en plasma juega un papel importante en la determinaci\u00f3n de des\u00f3rdenes endocrinol\u00f3gicos. Varios m\u00e9todos de gc\/ms se han desarrollado para la medici\u00f3n de las hormonas esteroideas o de sus metabolitos en el plasma. Sin embargo, por lo general requieren relativamente gran volumen de muestra (1-2 ml). En este trabajo, pretendemos poner a punto un m\u00e9todo para poder determinar un total de 17 hormonas esteroideas en plasma mediante gc\/ms y gc\/ms\/ms, mediremos la selectividad del m\u00e9todo, repetibilidad, reproducibilidad, l\u00edmites de detecci\u00f3n (ld), l\u00edmites de cuantificaci\u00f3n (lq), exactitud, linealidad, porcentaje de extracci\u00f3n, el fin \u00faltimo de todos ellos es un buen m\u00e9todo para determinar y cuantificar este grupo de hormonas esteroideas, desarrollando un procedimiento sencillo y con un gasto m\u00ednimo de muestra.  en relaci\u00f3n con la nandrolona, en 1997, en el \u00e1mbito de aplicaci\u00f3n del control antidoping en el deporte, un n\u00famero no desde\u00f1able de orinas analizadas por los laboratorios oficiales, revel\u00f3 la presencia de 19-norandrosterona (19-na) y 19-noretiocolanolona (19-ne). Estos resultados se repitieron en un corto per\u00edodo de tiempo y gener\u00f3 algunas investigaciones y, en particular, la verificaci\u00f3n de la posible producci\u00f3n de estos metabolitos por una ruta end\u00f3gena desconocida en todo adulto masculino. En el cuerpo humano, la nandrolona puede tener un origen end\u00f3geno o ex\u00f3geno. La presencia elevada de los metabolitos de la nandrolona en orina, puede tener como procedencia la anomal\u00eda de la actividad de los sistemas aromatasa. En este trabajo se pretende optimizar un m\u00e9todo para discernir entre la procedencia end\u00f3gena o ex\u00f3gena de los metabolitos de la nandrolona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cualificaci\u00f3n y cuantificaci\u00f3n de hormonas esteroideas en fluidos biol\u00f3gicos humanos (plasma y orina) mediante gc\/ms, gc\/ms-ms y lc\/ms.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cualificaci\u00f3n y cuantificaci\u00f3n de hormonas esteroideas en fluidos biol\u00f3gicos humanos (plasma y orina) mediante gc\/ms, gc\/ms-ms y lc\/ms. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Ferm\u00edn Toribio Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jes\u00fas Caballero Loscos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio S\u00e1nchez misiego <\/li>\n<li>argimiro Rodriguez jerez (vocal)<\/li>\n<li>roberto Carlos Izquierdo hornillos (vocal)<\/li>\n<li>Alberto Fern\u00e1ndez guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Ferm\u00edn Toribio Delgado La valoraci\u00f3n hormonal en plasma juega un papel importante en la determinaci\u00f3n de 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