{"id":10261,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/tiroiditis-de-hashimoto-caracterizacion-de-las-poblaciones-linfocitarias-antigenos-de-activacion-y-moleculas-de-adhesion-intercelulares\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"tiroiditis-de-hashimoto-caracterizacion-de-las-poblaciones-linfocitarias-antigenos-de-activacion-y-moleculas-de-adhesion-intercelulares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tiroiditis-de-hashimoto-caracterizacion-de-las-poblaciones-linfocitarias-antigenos-de-activacion-y-moleculas-de-adhesion-intercelulares\/","title":{"rendered":"Tiroiditis de hashimoto: caracterizacion de las poblaciones linfocitarias, antigenos de activacion y moleculas de adhesion intercelulares."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Gavilan Villarejo <\/strong><\/h2>\n<p>La tiroiditis de hashimoto (th) es una alteracion tiroidea, definida clinicamente por la existencia de bocio, anatomopatologicamente por un infiltrado linfocitario y funcionalmente por diversas situaciones:  eu, hipo o hipertiroidismo. Caracteristicamente se detectan niveles plasmaticos elevados de anticuerpos antitiroideos. Considerada una enfermedad de origen autoinmune cuya etiolog\u00eda es desconocida.  en los estudios realizados para analisis de poblaciones linfocitarias en sangre periferica existe gran discordancia entre los distintos autores, no estando bien definida la relacion existente con la funcion hormonal tiroidea. Son mas uniformes los resultados de estudios de receptores de activacion, que se detectan elevados en las enfermedades autoinmunes tiroideas. Un aspecto poco estudiado es la expresion en membrana linfocitaria de moleculas de adhesion, describiendose normales.  objetivos analisis de subpoblaciones linfocitarias en sangre periferica en th expresion en membrana linfocitaria de moleculas de adhesion estado de activacion funcional influencia de la funcion hormonal tiroidea sobre poblaciones linfocitarias.  resultados en th eutiroideos detectamos aumento de linfocitos t cd4 virgenes y activacion de linfocitos t cd4. Normalidad en el n. De linfocitos que expresaban moleculas de adhesion.  en th hipotiroideos se detecta disminucion de linfocitos t que expresan el receptor de membrana gamma\/delta y de la poblacion citotoxica t cd8 asi como elevacion de linfocitos t cd4 a expensas de la poblacion de memoria.  estas modificaciones se corrigen tras la resolucion farmacologica del hipotiroidismo, estableciendose correlaciones estadisticamente significativas entre estas subpoblaciones y la t4 libre y\/o tsh. Se detecta activacion de linfocitos t cd4 y normalidad del n. De linfocitos que expresan moleculas de adhesion en estos casos con independencia de la funcion hormonal.  conclusiones 1. En la th se detecta un<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tiroiditis de hashimoto: caracterizacion de las poblaciones linfocitarias, antigenos de activacion y moleculas de adhesion intercelulares.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tiroiditis de hashimoto: caracterizacion de las poblaciones linfocitarias, antigenos de activacion y moleculas de adhesion intercelulares. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Gavilan Villarejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gir\u00f3n Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lechuga Campoy <\/li>\n<li>Ricardo Astorga Jimenez (vocal)<\/li>\n<li>Alipio Mangas Rojas (vocal)<\/li>\n<li>Alfonso Leal Cerro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Gavilan Villarejo La tiroiditis de hashimoto (th) es una alteracion tiroidea, definida clinicamente por la existencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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