{"id":102627,"date":"2010-08-07T00:00:00","date_gmt":"2010-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nanosistemas-para-el-tratamiento-de-la-diabetes-mellitus-por-va%c2%ada-transmucosa\/"},"modified":"2010-08-07T00:00:00","modified_gmt":"2010-08-07T00:00:00","slug":"nanosistemas-para-el-tratamiento-de-la-diabetes-mellitus-por-va%c2%ada-transmucosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/nanosistemas-para-el-tratamiento-de-la-diabetes-mellitus-por-va%c2%ada-transmucosa\/","title":{"rendered":"Nanosistemas para el tratamiento de la diabetes mellitus por v\u00edatransmucosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angela Valle Gallego <\/strong><\/h2>\n<p>A pesar de los avances logrados en la b\u00fasqueda de nuevas formas farmac\u00e9uticas, el desaf\u00edo sobre la administraci\u00f3n de p\u00e9ptidos terap\u00e9uticos por v\u00edas no parenterales continua presente. Por ello, el objetivo principal de esta tesis ha sido el desarrollo de sistemas biocompatibles de tama\u00f1o nanom\u00e9trico capaces de vehiculizar insulina y exendina-4 a trav\u00e9s de la mucosa oral y\/o nasal, para el tratamiento de la diabetes mellitus. Con este fin, se investigaron sistemas espec\u00edficos para cada mol\u00e9cula. Para la administraci\u00f3n de insulina por v\u00eda oral, los nanocomplejos de lecitina insulina lograron reducir los niveles de glucosa en rata diab\u00e9tica. Aunque el mayor efecto sobre la glucemia se alcanz\u00f3 con la incorporaci\u00f3n de quitosano al sistema, originando nanopart\u00edculas de lecitina-quitosano. Por otra parte, la nanoc\u00e1psulas a base de lecitina-quitosano para la vehiculizaci\u00f3n de exendina-4, demostraron ser una herramienta eficaz para la administraci\u00f3n del p\u00e9ptido por v\u00eda nasal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nanosistemas para el tratamiento de la diabetes mellitus por v\u00edatransmucosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nanosistemas para el tratamiento de la diabetes mellitus por v\u00edatransmucosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angela Valle Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jose Alonso Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Remu\u00f1\u00e1n l\u00f3pez <\/li>\n<li>lucas carmelo Gonz\u00e1lez mat\u00edas (vocal)<\/li>\n<li>Ana isabel Vila pena (vocal)<\/li>\n<li>bruno filipe carmelino Cardoso sarmento (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angela Valle Gallego A pesar de los avances logrados en la b\u00fasqueda de nuevas formas farmac\u00e9uticas, el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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