{"id":102630,"date":"2010-08-07T00:00:00","date_gmt":"2010-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-epigenetico-del-asma-alergica-mediante-el-analisis-de-patrones-de-metilacion\/"},"modified":"2010-08-07T00:00:00","modified_gmt":"2010-08-07T00:00:00","slug":"estudio-epigenetico-del-asma-alergica-mediante-el-analisis-de-patrones-de-metilacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hipersensibilidad\/estudio-epigenetico-del-asma-alergica-mediante-el-analisis-de-patrones-de-metilacion\/","title":{"rendered":"Estudio epigen\u00e9tico del asma al\u00e9rgica mediante el an\u00e1lisis de patrones de metilaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mari\u00e9n Pascual De Pedro <\/strong><\/h2>\n<p>A pesar de que no hay duda sobre la influencia que la predisposci\u00f3n g\u00e9nica tiene en la susceptibilidad individual a sufrir una enfermedad al\u00e9rgica, se necesitan estudios de asociaci\u00f3n del epigenoma (epigenome wide association studies) para entender la posible relaci\u00f3n entre las enfermedades al\u00e9rgicas y la desregulaci\u00f3n epigen\u00e9tica. En este trabajo nos propusimos analizar los patrones epigen\u00e9ticos, en t\u00e9rminos de metilaci\u00f3n de citosinas, de dos poblaciones bien caracterizadas: asm\u00e1ticos y al\u00e9rgicos a \u00e1caros del polvo y controles. Para ello, empleamos una t\u00e9cnica conocida como help (hpa ii tiny fragments enrichment by ligation mediated pcr) assay en una poblaci\u00f3n celular aislada de sangre perif\u00e9rica, linfocitos b cd19+. Se encontraron diferencias epigen\u00e9ticas a nivel global en esta l\u00ednea celular entre ambos grupos, las cuales correspond\u00edan principalmente a cascadas de transmisi\u00f3n de se\u00f1ales celulares relacionadas con el sistema inmune. Adem\u00e1s, se identific\u00f3 un nuevo gen candidato, cyp26a1, que presenta patrones de metilaci\u00f3n y expresi\u00f3n diferencial entre ambos grupos. Estos resultados sugieren que la desregulaci\u00f3n epigen\u00e9tica podr\u00eda ser una causa influyente en el desarrollo de las enfermedades al\u00e9rgicas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio epigen\u00e9tico del asma al\u00e9rgica mediante el an\u00e1lisis de patrones de metilaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio epigen\u00e9tico del asma al\u00e9rgica mediante el an\u00e1lisis de patrones de metilaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mari\u00e9n Pascual De Pedro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>F\u00e9lix Lorente Toledano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Blanco quiros <\/li>\n<li>Jes\u00fas Prieto veiga (vocal)<\/li>\n<li>Santiago Quirce gancedo (vocal)<\/li>\n<li>Francisco Guerra  pasadas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mari\u00e9n Pascual De Pedro A pesar de que no hay duda sobre la influencia que la predisposci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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