{"id":102698,"date":"2010-09-07T00:00:00","date_gmt":"2010-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/development-of-new-strategies-for-the-synthesis-of-radiotracers-labeled-with-short-lived-isotopes-application-to-11c-and-13n\/"},"modified":"2010-09-07T00:00:00","modified_gmt":"2010-09-07T00:00:00","slug":"development-of-new-strategies-for-the-synthesis-of-radiotracers-labeled-with-short-lived-isotopes-application-to-11c-and-13n","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/development-of-new-strategies-for-the-synthesis-of-radiotracers-labeled-with-short-lived-isotopes-application-to-11c-and-13n\/","title":{"rendered":"Development of new strategies for the synthesis of radiotracers labeled with short-lived isotopes: application to 11c and 13n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vanessa G\u00f3mez Vallejo <\/strong><\/h2>\n<p>Se ha desarrollado una nueva estrategia para la s\u00edntesis r\u00e1pida y eficiente de l-[metil-11c]metionina basada en el captive solvent method. La reacci\u00f3n de l-homociste\u00edna (disoluci\u00f3n b\u00e1sica en agua\/etanol 1:1) con [11c]ch3i en un loop de hplc permiti\u00f3 la formaci\u00f3n del radiotrazador deseado con elevado rendimiento radioqu\u00edmico (38.4 \u00c2\u00b1 4.1%) en un tiempo corto (< 12 min). Todos los par\u00e1metros anal\u00edticos cumpl\u00edan las especificaciones requeridas por la versi\u00f3n actual de la farmacopea espa\u00f1ola, aunque los valores de actividad espec\u00edfica obtenidos fueron relativamente bajos. Por ello, se estudiaron y cuantificaron las principales fuentes que contribuyen a la contaminaci\u00f3n de carbono-12 durante las s\u00edntesis de [11c]ch3i efectuadas seg\u00fan el \"wet\" method. Se observ\u00f3 que la principal fuente de contaminaci\u00f3n de co2 no radiactivo (contribuci\u00f3n>90%) es el propio proceso de bombardeo, probablemente debido a la combusti\u00f3n (causada por las altas temperaturas y presiones alcanzadas durante la irradiaci\u00f3n) de los compuestos que contienen carbono y que se encuentran presentes en el gas irradiado (o en el mismo cuerpo del blanco). Se establecieron procedimientos generales para realizar antes, durante y con posterioridad a la radios\u00edntesis para prevenir la contaminaci\u00f3n exterior y, de esta manera, aumentar la actividad espec\u00edfica de los radiotrazadores sintetizados. respecto al marcaje con nitr\u00f3geno-13, se ha desarrollado un proceso totalmente autom\u00e1tico para la producci\u00f3n de [13n]no2- a partir del [13n]no3- generado en el ciclotr\u00f3n. El precursor radiactivo [13n]no2- se ha utilizado para la radios\u00edntesis de compuestos con inter\u00e9s biol\u00f3gico tales como s-nitrosotioles (donadores de no.), N-nitrosaminas (mol\u00e9culas con potenciales efectos carcinog\u00e9nicos) y azo compuestos (con posible aplicaci\u00f3n como radiotrazadores para la detecci\u00f3n in vivo de placas de \u00edY-amiloide). En todos los casos se obtuvieron excelentes conversiones radioqu\u00edmicas (48.7% &#8211; 74.5% para s-[13n]nitrosotioles, 45.6% &#8211; 53.4% para n-[13n]nitrosaminas y 40.0% &#8211; 58.3% para 13n-azo compuestos) y buenos rendimientos radioqu\u00edmicos (33.8% &#8211; 60.6% para s-[13n]nitrosotioles, 34.0% &#8211; 37.8% para n-[13n]nitrosaminas y 20.4% &#8211; 47.2% para 13n-azo compuestos). Adem\u00e1s, se ha dise\u00f1ado e implementado un m\u00f3dulo autom\u00e1tico con control remoto para el marcaje de mol\u00e9culas con 13n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Development of new strategies for the synthesis of radiotracers labeled with short-lived isotopes: application to 11c and 13n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Development of new strategies for the synthesis of radiotracers labeled with short-lived isotopes: application to 11c and 13n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vanessa G\u00f3mez Vallejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ram\u00f3n llull<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Llop Roig<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Nonell marrugat <\/li>\n<li>torsten Reese (vocal)<\/li>\n<li>gemma Arsequell ruiz (vocal)<\/li>\n<li>jacek Koziorowski (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vanessa G\u00f3mez Vallejo Se ha desarrollado una nueva estrategia para la s\u00edntesis r\u00e1pida y eficiente de l-[metil-11c]metionina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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