{"id":102999,"date":"2018-03-11T10:25:20","date_gmt":"2018-03-11T10:25:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-experimental-de-osteonecrosis-producida-por-bisfosfonatos-nitrogenados\/"},"modified":"2018-03-11T10:25:20","modified_gmt":"2018-03-11T10:25:20","slug":"estudio-experimental-de-osteonecrosis-producida-por-bisfosfonatos-nitrogenados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/estudio-experimental-de-osteonecrosis-producida-por-bisfosfonatos-nitrogenados\/","title":{"rendered":"Estudio experimental de osteonecrosis producida por bisfosfonatos nitrogenados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ascension Martinez Canovas <\/strong><\/h2>\n<p>Objetivos: el objetivo general de este trabajo fue estudiar mediante un modelo experimental, el riesgo de onm en ratas sprague-dawley tratadas con pamidronato dis\u00f3dico y dexametasona, o tratadas adem\u00e1s con un antibi\u00f3tico de amplio espectro. metodolog\u00eda: se incluyeron un total de 130 ratas hembras adultas. Separadas homog\u00e9neamente en dos grupos de estudio. En el grupo i se administr\u00f3 pamidronato y dexametasona durante 7, 14 y 21 d\u00edas y en el grupo ii se administraron estos dos f\u00e1rmacos junto con bencilpenicilina s\u00f3dica. En ambos grupos se realizaron exodoncias de molares derechos en maxilar o mand\u00edbula a los 8, 15 y 22 d\u00edas. Fueron sacrificadas, tras la finalizaci\u00f3n del tratamiento, a los 14 o 28 d\u00edas. Se analiz\u00f3 la presencia de osteonecrosis maxilar: su extensi\u00f3n cl\u00ednica y radiol\u00f3gica, par\u00e1metros histol\u00f3gicos y los niveles de ca y p en mand\u00edbula y cabeza de f\u00e9mur. resultados: reducci\u00f3n del n\u00famero de osteonecrosis (p= 0,002) y la extensi\u00f3n radiol\u00f3gica (p= 0,021) con diferencias estad\u00edsticamente significativas, en el grupo tratado en bencilpenicilina s\u00f3dica. Los niveles de ca y p son mayores en mand\u00edbula que en cabeza de f\u00e9mur con diferencias estad\u00edsticamente significativas (p=0,007 y p= 0,013) a partir de los 21 d\u00edas de dosis acumulada. conclusiones: la administraci\u00f3n de un tratamiento antibi\u00f3tico preventivo reduce el riesgo de aparici\u00f3n de osteonecrosis maxilares y su extensi\u00f3n cl\u00ednica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experimental de osteonecrosis producida por bisfosfonatos nitrogenados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experimental de osteonecrosis producida por bisfosfonatos nitrogenados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ascension Martinez Canovas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fabio Camacho Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isabel Fernandez tresguerres hernandez gil <\/li>\n<li>Rafael Segura saint-gerons (vocal)<\/li>\n<li>Luis Alberto Moreno lopez (vocal)<\/li>\n<li>Manuel Jos\u00e9 Saura perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ascension Martinez Canovas Objetivos: el objetivo general de este trabajo fue estudiar mediante un modelo experimental, el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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