{"id":103108,"date":"2018-03-11T10:25:31","date_gmt":"2018-03-11T10:25:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/busqueda-y-validacion-de-biomarcadores-sericos-de-prediccion-de-respuesta-a-docetaxel-y-doxorubicina-en-cancer-de-mama-mediante-tecnicas-proteomicas\/"},"modified":"2018-03-11T10:25:31","modified_gmt":"2018-03-11T10:25:31","slug":"busqueda-y-validacion-de-biomarcadores-sericos-de-prediccion-de-respuesta-a-docetaxel-y-doxorubicina-en-cancer-de-mama-mediante-tecnicas-proteomicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/busqueda-y-validacion-de-biomarcadores-sericos-de-prediccion-de-respuesta-a-docetaxel-y-doxorubicina-en-cancer-de-mama-mediante-tecnicas-proteomicas\/","title":{"rendered":"B\u00fasqueda y validaci\u00f3n de biomarcadores s\u00e9ricos de predicci\u00f3n de respuesta a docetaxel y doxorubicina en c\u00e1ncer de mama mediante t\u00e9cnicas prote\u00f3micas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nerea Torres Antunez <\/strong><\/h2>\n<p>El c\u00e1ncer de mama supone el 20% de todos los tipos de c\u00e1ncer en mujeres, diagnostic\u00e1ndose cada a\u00f1o aproximadamente 1 mill\u00f3n de nuevos casos en todo el mundo. A pesar de los avances en diagn\u00f3stico y terapia, el c\u00e1ncer de mama contin\u00faa siendo el causante de 350.000 muertes anuales, con una tasa de supervivencia a los 5 a\u00f1os de 7% a 36% en los casos m\u00e1s avanzados de c\u00e1ncer (carcinomas localmente avanzados). Los principales tratamientos frente a estos carcinomas son quimioterapias basadas en antraciclinas y taxanos, que pueden presentar hasta un 30-50% de resistencia. Actualmente no existen sistemas de predicci\u00f3n de respuesta a estos tratamientos. en este proyecto de tesis doctoral se ha estudiado el proteoma del suero de pacientes con c\u00e1ncer de mama localmente avanzado, en muestras recogidas antes de comenzar  el tratamiento con doxorubicina o con docetaxel. Se ha comparado el proteoma s\u00e9rico entre pacientes sensibles y resistentes evaluando su respuesta a ambos tratamientos seg\u00fan el criterio rcb, que se basa en par\u00e1metros del tumor medidos en el momento de la cirug\u00eda tras la quimioterapia. Se han identificado un conjunto de prote\u00ednas s\u00e9ricas diferenciales entre pacientes sensibles y resistentes a tratamiento con doxorubicina y docetaxel y se han validado las de mayor inter\u00e9s como potenciales biomarcadores de predicci\u00f3n de respuesta a ambos agentes quimioter\u00e1picos. De esta forma, se ha pretendido profundizar en el conocimiento actual de la respuesta a terapia en c\u00e1ncer de mama y aportar en el desarrollo de nuevas herramientas de aplicaci\u00f3n cl\u00ednica en este campo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>B\u00fasqueda y validaci\u00f3n de biomarcadores s\u00e9ricos de predicci\u00f3n de respuesta a docetaxel y doxorubicina en c\u00e1ncer de mama mediante t\u00e9cnicas prote\u00f3micas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 B\u00fasqueda y validaci\u00f3n de biomarcadores s\u00e9ricos de predicci\u00f3n de respuesta a docetaxel y doxorubicina en c\u00e1ncer de mama mediante t\u00e9cnicas prote\u00f3micas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nerea Torres Antunez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Serra Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodriguez arrondo <\/li>\n<li>felix Elortza basterrika (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<li>rub\u00e9n Pio os\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nerea Torres Antunez El c\u00e1ncer de mama supone el 20% de todos los tipos de c\u00e1ncer en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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