{"id":103302,"date":"2018-03-11T10:25:51","date_gmt":"2018-03-11T10:25:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cla%c2%adnico-y-genetico-de-la-degeneracion-macular-asociada-a-la-edad\/"},"modified":"2018-03-11T10:25:51","modified_gmt":"2018-03-11T10:25:51","slug":"estudio-cla%c2%adnico-y-genetico-de-la-degeneracion-macular-asociada-a-la-edad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oftalmologia\/estudio-cla%c2%adnico-y-genetico-de-la-degeneracion-macular-asociada-a-la-edad\/","title":{"rendered":"Estudio cl\u00ednico y gen\u00e9tico de la degeneraci\u00f3n macular asociada a la edad"},"content":{"rendered":"

Tesis doctoral de Fernando Cruz Gonzalez <\/strong><\/h2>\n

Introducci\u00f3n: \tla degeneraci\u00f3n macular asociada a la edad (dmae) es una de las patolog\u00edas m\u00e1s importantes en oftalmolog\u00eda debido a su preValencia y a la gran p\u00e9rdida visual que se asocia a ella. pacientes y m\u00e9todos: \tpara nuestro estudio tomamos 101 pacientes diagnosticados de dmae en el servicio de oftalmolog\u00eda del hospital cl\u00ednico de salamanca. De estos 56 eran mujeres y 45 hombres y la edad media era de 77,750 – 7,198 a\u00f1os. Como control se usaron 91 sujetos sin dmae ni alteraciones maculares significativas revisados en el hospital cl\u00ednico de salamanca. A todos los sujetos se les realiz\u00f3 un estudio de un polimorfismo de un solo nucle\u00f3tido (snp) de los genes arms 2, cfh, htra 1, vegf a y vegfr 2 en relaci\u00f3n con la susceptibilidad a padecer dmae y con la respuesta al tratamiento con ranibizumab intrav\u00edtreo resultados: \ten la poblaci\u00f3n incluida en nuestro estudio, el riesgo de padecer degeneraci\u00f3n macular se asocia con los genotipos gg del polimorfismo rs 1410996 del gen cfh (or: 2,176), tt del polimorfismo rs 1040924 del gen arms2 (or: 6,369) , gg del polimorfismo htra1 -625 (or:3,324) y gg del polimorfismo rs 2071559 del gen vegfr2 (or:2,010) \tlos genotipos del polimorfismo rs 1410996 del gen cfh, rs 833061 de vegf a y rs 2071559 de vegfr 2 se asocian con cambios en la respuesta al tratamiento con ranibizumab intrav\u00edtreo (p<0,05) conclusiones: \tnuestro trabajo confirma que variantes al\u00e9licas de los genes cfh, amrs2, htra1 y vegfr modifican el riesgo de padecer dmae. \tla respuesta al tratamiento con ranibizumab intrav\u00edtreo est\u00e1 moderadamente influenciada por polimorfismos de los genes cfh y vegfr, lo que, de confirmarse en otras series, abre la posibilidad de su utilizaci\u00f3n como marcador farmacogen\u00e9tico.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abEstudio cl\u00ednico y gen\u00e9tico de la degeneraci\u00f3n macular asociada a la edad<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednico y gen\u00e9tico de la degeneraci\u00f3n macular asociada a la edad <\/li>\n
  • Autor:<\/strong>\u00a0 Fernando Cruz Gonzalez <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Jos\u00e9 Mar\u00eda Barahona hortelano <\/li>\n
        • bego\u00f1a Baamonde arbaiza (vocal)<\/li>\n
        • Mar\u00eda Jimena rojas (vocal)<\/li>\n
        • Antonio Pi\u00f1ero bustamante (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Fernando Cruz Gonzalez Introducci\u00f3n: la degeneraci\u00f3n macular asociada a la edad (dmae) es una de las patolog\u00edas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[988,9386],"tags":[4405,67487,209231,193768,138995,26315],"class_list":["post-103302","post","type-post","status-publish","format-standard","hentry","category-oftalmologia","category-salamanca","tag-antonio-pinero-bustamante","tag-begona-baamonde-arbaiza","tag-fernando-cruz-gonzalez","tag-jose-maria-barahona-hortelano","tag-maria-jimena-rojas","tag-rogelio-gonzalez-sarmiento"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=103302"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103302\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=103302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=103302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=103302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}