{"id":103394,"date":"2018-03-11T10:25:56","date_gmt":"2018-03-11T10:25:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunopatologico-de-la-respuesta-inducida-por-el-antigeno-recombinante-sm14-en-la-fasciolosis-caprina\/"},"modified":"2018-03-11T10:25:56","modified_gmt":"2018-03-11T10:25:56","slug":"estudio-inmunopatologico-de-la-respuesta-inducida-por-el-antigeno-recombinante-sm14-en-la-fasciolosis-caprina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-veterinaria\/estudio-inmunopatologico-de-la-respuesta-inducida-por-el-antigeno-recombinante-sm14-en-la-fasciolosis-caprina\/","title":{"rendered":"Estudio inmunopatologico de la respuesta inducida por el antigeno recombinante sm14 en la fasciolosis caprina"},"content":{"rendered":"

Tesis doctoral de Ricardo Evandro Mendes <\/strong><\/h2>\n

La fasciolosis es una parasitosis econ\u00f3micamente importante en rumiantes en todo el mundo. El ant\u00edgeno sm14 es una prote\u00edna transportadora de \u00e1cidos grasos (fatty acid binding protein) aislada del trematodo schistosoma mansoni que induce una protecci\u00f3n cruzada frente a fasciola hepatica en ratones y ovejas. para este estudio se usaron 45 cabras de raza florida sevillana, divididas en seis grupos: grupo 1 (inmunizado con el adyuvante quil a); grupo 2 (rsm14 + quil a) y grupo 3 (no inmunizado); grupo 4 (inmunizado con el adyuvante ribi); grupo 5 (rsm14 + ribi); y grupo 6 (no inmunizado). Los grupos inmunizados fueron infectados a las 10 semanas con 200 metacercarias de f. Hepatica oralmente. tras la necropsia se realiz\u00f3 un recuento de par\u00e1sitos hep\u00e1ticos y se tomaron muestras. La caracterizaci\u00f3n de la respuesta inmunitaria local a nivel hep\u00e1tico y de n\u00f3dulos linf\u00e1ticos hep\u00e1ticos se realiz\u00f3 mediante t\u00e9cnicas inmunohistoqu\u00edmicas. No se observ\u00f3 reducci\u00f3n en la carga parasitaria ni tampoco diferencias a nivel del estudio morfom\u00e9trico microsc\u00f3pico. el infiltrado celular hep\u00e1tico y a nivel de n\u00f3dulos linf\u00e1ticos hep\u00e1ticos fue m\u00e1s reducido en los grupos inmunizados con el rsm14, constat\u00e1ndose menores contajes de c\u00e9lulas inmunorreactivas para los ant\u00edgenos cd2+, cd4+, cd8+, as\u00ed como un menor n\u00famero de linfocitos t \u00c2\u00bf\u00c2\u00bf+ y menor expresi\u00f3n de, il-4+ e ifn-\u00c2\u00bf+ (p<0.05). La inmunizaci\u00f3n redujo el da\u00f1o hep\u00e1tico macrosc\u00f3picamente y produjo una respuesta inmunitaria local menos severa. dado que no hubo diferencias en el n\u00famero de par\u00e1sitos, ser\u00eda interesante realizar estudios en fases iniciales de la migraci\u00f3n para dilucidar los mecanismos de respuesta inmunitaria en animales vacunados y no vacunados. Las respuestas inmunitarias no presentaron car\u00e1cter protector en ning\u00fan de los experimentos, ya que a pesar de intensas, no indujeron una reducci\u00f3n significativa de la carga parasitaria.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abEstudio inmunopatologico de la respuesta inducida por el antigeno recombinante sm14 en la fasciolosis caprina<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunopatologico de la respuesta inducida por el antigeno recombinante sm14 en la fasciolosis caprina <\/li>\n
  • Autor:<\/strong>\u00a0 Ricardo Evandro Mendes <\/li>\n
  • Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 28\/07\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Alvaro Martinez Moreno<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Elena Mozos mora <\/li>\n
        • Antonio Espinosa monteros y zayas (vocal)<\/li>\n
        • Francisco j. Salguero bodes (vocal)<\/li>\n
        • david Reina esojo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Ricardo Evandro Mendes La fasciolosis es una parasitosis econ\u00f3micamente importante en rumiantes en todo el mundo. El […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,20868,661,495],"tags":[55457,189715,54874,8485,40657,209383],"class_list":["post-103394","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-inmunologia-veterinaria","category-parasitologia-animal","category-patologia-veterinaria","tag-alvaro-Martinez-moreno","tag-antonio-espinosa-monteros-y-zayas","tag-david-reina-esojo","tag-elena-mozos-mora","tag-francisco-j-salguero-bodes","tag-ricardo-evandro-mendes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=103394"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103394\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=103394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=103394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=103394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}