{"id":103490,"date":"2010-06-09T00:00:00","date_gmt":"2010-06-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neurobiological-mechanisms-involved-in-mdma-seeking-behaviour-and-relapse\/"},"modified":"2010-06-09T00:00:00","modified_gmt":"2010-06-09T00:00:00","slug":"neurobiological-mechanisms-involved-in-mdma-seeking-behaviour-and-relapse","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pompeu-fabra\/neurobiological-mechanisms-involved-in-mdma-seeking-behaviour-and-relapse\/","title":{"rendered":"Neurobiological mechanisms involved in mdma-seeking behaviour and relapse"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Juliana Orejarena Serrano <\/strong><\/h2>\n<p>(+) 3,4-metilendioximetanfetamina (mdma), popularmente conocida como \u00ab\u00e9xtasis\u00bb, es una droga susceptible de producir adicci\u00f3n en algunos individuos. Actualmente es consumida principalmente por adolescentes y  j\u00f3venes. Los particulares efectos psicoact\u00edvos inducidos por la mdma, permiten distinguirlo de manera clara de otros psicoestimulantes o compuestos alucin\u00f3genos. Esta droga act\u00faa principalmente activando el sistema dopamin\u00e9rgico y seroton\u00e9rgico en los circuitos neurales de placer. Sin embargo, los mecanismos neurobiol\u00f3gicos implicados en las propiedades adictivas de esta droga no han sido a\u00fan esclarecidos.  el trabajo presentado en esta tesis doctoral ha puesto de manifiesto algunos aspectos claves de estos procesos que eran desconocidos hasta el momento. Hemos encontrado que el receptor de serotonina 5-ht 2a participa de forma cr\u00edtica en las propiedades reforzantes de la mdma, contrario a lo observado en el caso de otros psicoestimulantes. Adem\u00e1s, el bloqueo farmacol\u00f3gico de este receptor puede prevenir la reinstauraci\u00f3n de la b\u00fasqueda de la mdma, desencadenada por un est\u00edmulo o clave previamente asociado a su consumo. Estos efectos pueden ser debidos al bloqueo del control excitatorio que normalmente ejercen estos receptores sobre los niveles de dopamina en estructuras mesol\u00edmbicas, como ha sido revelado en nuestros estudios de microdi\u00e1lisis. Hemos demostrado tambi\u00e9n que la mdma puede actuar como clave interoceptiva y desencadenar la reca\u00edda a la b\u00fasqueda y consumo de coca\u00edna. Adicionalmente, nuestros estudios han mostrado que tanto la activaci\u00f3n del sistema dopamin\u00e9rgico mesol\u00edmbico, como los cambios en la expresi\u00f3n g\u00e9nica en diferentes \u00e1reas cerebrales que ocurren tras la administraci\u00f3n de la mdma, dependen de si el sujeto participa de manera activa en el consumo de esta droga, o si por el contrario la recibe de forma pasiva. En conclusi\u00f3n, este trabajo resalta la importancia de los procesos de aprendizaje y memoria sobre las propiedades reforzantes\/recompensantes de la mdma. Adem\u00e1s, nuestras investigaciones aportan nuevas evidencias en relaci\u00f3n a la participaci\u00f3n del sistema seroton\u00e9rgico en la busqueda  y reca\u00edda al consumo de esta droga.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neurobiological mechanisms involved in mdma-seeking behaviour and relapse<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neurobiological mechanisms involved in mdma-seeking behaviour and relapse <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Juliana Orejarena Serrano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Maldonado L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael De la torre fornell <\/li>\n<li>miquel Martin sanchez (vocal)<\/li>\n<li>Francisco Artigas p\u00e9rez (vocal)<\/li>\n<li>Jorge Manzanares robles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Juliana Orejarena Serrano (+) 3,4-metilendioximetanfetamina (mdma), popularmente conocida como \u00ab\u00e9xtasis\u00bb, es una droga susceptible de producir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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