{"id":103583,"date":"2010-10-09T00:00:00","date_gmt":"2010-10-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/las-islas-de-patogenicidad-de-staphylococcus-aureus-parasitan-la-maquinaria-de-los-bacteriofagos-para-su-empaquetamiento-y-transferencia-horizontal\/"},"modified":"2010-10-09T00:00:00","modified_gmt":"2010-10-09T00:00:00","slug":"las-islas-de-patogenicidad-de-staphylococcus-aureus-parasitan-la-maquinaria-de-los-bacteriofagos-para-su-empaquetamiento-y-transferencia-horizontal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/las-islas-de-patogenicidad-de-staphylococcus-aureus-parasitan-la-maquinaria-de-los-bacteriofagos-para-su-empaquetamiento-y-transferencia-horizontal\/","title":{"rendered":"Las islas de patogenicidad de staphylococcus aureus parasitan la maquinaria de los bacteri\u00f3fagos para su empaquetamiento y transferencia horizontal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa Desamparados Ferrer Garc\u00eda <\/strong><\/h2>\n<p>Es bien sabido que los elementos gen\u00e9ticos m\u00f3viles tales como transposones, pl\u00e1smidos, bacteri\u00f3fagos e islas de patogenicidad, juegan un papel crucial en la difusi\u00f3n de genes de patogenicidad entre poblaciones bacterianas. En staphylococcus aureus, se han descrito varias islas de patogenicidad (sapis), asumi\u00e9ndose en la actualidad que todas las cepas cl\u00ednicas presentan al menos uno de estos elementos gen\u00e9ticos (novick y subedi, 2007). Las sapis forman una gran familia de elementos gen\u00e9ticos m\u00f3viles relacionados estrechamente con fagos. As\u00ed, las islas pueden ser movilizadas mediante la infecci\u00f3n con fagos de cepas sensibles o mediante la inducci\u00f3n de profagos residentes.  nuestro estudio se ha centrado en la caracterizaci\u00f3n gen\u00e9tica del bacteri\u00f3fago11 originalmente aislado de la cepa 8325 de s. Aureus. Tras el estudio de la regulaci\u00f3n de las diferentes etapas del ciclo del fago, hemos podido observar que el regulador transcripcional rina, necesario para la activaci\u00f3n de la expresi\u00f3n del gen que codifica para la integrasa del fago, tambi\u00e9n es imprescindible para la expresi\u00f3n del gen de la terminasa peque\u00f1a del fago y por consiguiente para el empaquetamiento del mismo.  por otro lado, puesto que las islas de patogenicidad utilizan las prote\u00ednas codificadas por el fago para su propia transferencia, observamos que en el mutante en rina no existen part\u00edculas transductantes de isla, ya que \u00e9stas tambi\u00e9n son incapaces de transferirse.   del mismo modo pensamos que rina est\u00e1 involucrado, en la regulaci\u00f3n de los genes l\u00edticos, puesto que tras inducir con mitomicina c el mutante rina del fago, no se observa la lisis del cultivo propia de la cepa salvaje.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Las islas de patogenicidad de staphylococcus aureus parasitan la maquinaria de los bacteri\u00f3fagos para su empaquetamiento y transferencia horizontal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Las islas de patogenicidad de staphylococcus aureus parasitan la maquinaria de los bacteri\u00f3fagos para su empaquetamiento y transferencia horizontal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa Desamparados Ferrer Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cardenal herrera-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mari Angeles Tormo Mas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  evaristo Suarez fernandez <\/li>\n<li>Rafael Sanju\u00e1n verdeguez (vocal)<\/li>\n<li>Mar\u00eda teresa Muniesa p\u00e9rez (vocal)<\/li>\n<li>pilar Garcia suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa Desamparados Ferrer Garc\u00eda Es bien sabido que los elementos gen\u00e9ticos m\u00f3viles tales como transposones, pl\u00e1smidos, bacteri\u00f3fagos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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